ArticlePloS one2022
Synaptic counts approximate synaptic contact area in Drosophila.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Prediction of neural activity in connectome-constrained recurrent networks.Nature neuroscience · 2025Article
- Article
- Article
- Article
- Prediction of neural activity in connectome-constrained recurrent networks.bioRxiv : the preprint server for biology · 2024Article
- Morphology and synapse topography optimize linear encoding of synapse numbers inbioRxiv : the preprint server for biology · 2024Article
- Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024Article
- Evaluating traces of Hebbian plasticity in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Reply to Castro et al.: Do connectomes possess markers of activity-dependent synaptic plasticity?Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila.Nature communications · 2023Article
- Normative and mechanistic model of an adaptive circuit for efficient encoding and feature extraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- Compensatory variability in network parameters enhances memory performance in theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- A connectome of theeLife · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The pattern of synaptic connections among neurons defines the circuit structure, which constrains the computations that a circuit can perform. The strength of synaptic connections is costly to measure yet important for accurate circuit modeling. Synaptic surface area has been shown to correlate with synaptic strength, yet in the emerging field of connectomics, most studies rely instead on the counts of synaptic contacts between two neurons. Here we quantified the relationship between synaptic count and synaptic area as measured from volume electron microscopy of the larval Drosophila central nervous system. We found that the total synaptic surface area, summed across all synaptic contacts from one presynaptic neuron to a postsynaptic one, can be accurately predicted solely from the number of synaptic contacts, for a variety of neurotransmitters. Our findings support the use of synaptic counts for approximating synaptic strength when modeling neural circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.