ArticleNeuropsychology2022
Intraindividual variability in neuropsychological performance predicts longitudinal cortical volume loss in early Parkinson's disease.
Article in Neuropsychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression.medRxiv : the preprint server for health sciences · 2026Article
- The neurophysiological brain-fingerprint of Parkinson's disease.EBioMedicine · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- Moving intra-individual variability (IIV) towards clinical utility: IIV measured using a commercial testing platform.Journal of the neurological sciences · 2023Article
- Intra-individual variability in cognitive performance predicts functional decline in Parkinson's disease.Applied neuropsychology. AdultArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveCognitive impairment is common among individuals with Parkinson's disease (PD). Intraindividual variability (IIV) is a measure of variability across multiple tasks of cognitive functioning. Due to the limited amount of research, particularly among individuals with PD, IIV has been an underutilized metric of cognitive functioning both in research and clinical practice. Previous research demonstrated that individuals with PD have greater variability in cognitive performance relative to controls, and that IIV is predictive of future cognitive impairments. The aim of this study is to investigate the association between baseline IIV and change in cortical and subcortical volumes among individuals with PD.
methodThe present study used data from 80 newly diagnosed PD patients who were part of a longitudinal cohort study (Parkinson progression marker initiative [PPMI]). Participants completed neuropsychological measures and underwent T1 structural magnetic resonance imaging (MRI) at baseline and the first annual follow-up. Neuropsychological tests assessed attention, processing speed, visuospatial functioning, verbal fluency learning, and memory. T1 scans were processed using standard Freesurfer protocols for extraction of regional volumes.
resultsGreater IIV at baseline was predictive of change in cortical volume in posterior temporal/parietal regions over the 1-year period. Baseline IIV predicted cortical volume changes above and beyond the main effect of motor severity and the baseline statistical mean/global cognition score.
conclusionOur results provide initial evidence that IIV is a marker of longitudinal cortical volume loss. Evidence is building that IIV is a sensitive marker of cognitive impairment and the underlying neurodegeneration among individuals with PD. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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