Evidence map›Paper›PMID 35377289›Full record

SynthesisGlobal health action2021

Maternal mortality in the covid-19 pandemic: findings from a rapid systematic review.

Clara Calvert, Jeeva John, Farirai P Nzvere, Jenny A Cresswell, Sue Fawcus, Edward Fottrell, Lale Say, Wendy J Graham

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Global health action, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Clara CalvertCentre for Global Health, Usher Institute, University of Edinburgh, UK.ORCID 0000-0003-3272-1040
Jeeva JohnCentre for Global Health, Usher Institute, University of Edinburgh, UK.ORCID 0000-0001-9651-4193
Farirai P NzvereCentre for Global Health, Usher Institute, University of Edinburgh, UK.
Jenny A CresswellUNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-9553-1132
Sue FawcusDepartment of Obstetrics and Gynaecology, University of Cape Town, Rondebosch, South Africa.ORCID 0000-0002-1818-7171
Edward FottrellUCL Institute for Global Health, Faculty of Population Health Sciences, University College London, London, UK.ORCID 0000-0003-0518-7161
Lale SayUNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-1377-1328
Wendy J GrahamDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, UK.ORCID 0000-0003-1473-5342
London School of Hygiene & Tropical Medicine · GBUniversity of Edinburgh · GBWorld Health Organization · CHUniversity College London · GBUniversity of Cape Town · ZA

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic is having significant direct and associated effects on many health outcomes, including maternal mortality. As a useful marker of healthcare system functionality, trends in maternal mortality provide a lens to gauge impact and inform mitigation strategies.

objectiveTo report the findings of a rapid systematic review of studies on levels of maternal mortality before and during the COVID-19 pandemic.

methodsWe systematically searched for studies on the 1st March 2021 in MEDLINE and Embase, with additional studies identified through MedRxiv and searches of key websites. We included studies that reported levels of mortality in pregnant and postpartum women in time-periods pre- and during the COVID-19 pandemic. The maternal mortality ratio was calculated for each study as well as the excess mortality.

resultsThe search yielded 3411 references, of which five studies were included in the review alongside two studies identified from grey literature searches. Five studies used data from national health information systems or death registries (Mexico, Peru, Uganda, South Africa, and Kenya), and two studies from India were record reviews from health facilities. There were increased levels of maternal mortality documented in all studies; however, there was only statistical evidence for a difference in maternal mortality in the COVID-19 era for four of these. Excess maternal mortality ranged from 8.5% in Kenya to 61.5% in Uganda.

conclusionsMeasuring maternal mortality in pandemics presents many challenges, but also essential opportunities to understand and ameliorate adverse impact both for women and their newborns. Our systematic review shows a dearth of studies giving reliable information on levels of maternal mortality, and we call for increased and more systematic reporting of this largely preventable outcome. The findings help to highlight four measurement-related issues which are priorities for continuing research and development.

Indexed as

COVID-19FamilyFemaleHealth FacilitiesHumansInfant, NewbornMaternal MortalityPandemicsPregnancyMaternal deathsmaternal mortality ratiorapid systematic reviewSars-Cov-2

Identifiers

PMID35377289
PMCPMC8986253
OpenAlexW4285342295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.