ArticleMolecular and cellular biology1986
Isolation of mip (microtubule-interacting protein) mutations of Aspergillus nidulans.
Article in Molecular and cellular biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 83 citations in OpenAlex.
- Tubulin autoregulation factors SCAPER and TTC5 recruit γ-tubulin to non-centrosomal MTOCs for neuronal microtubule nucleation and axon regeneration.bioRxiv : the preprint server for biology · 2025Article
- Microtubule nucleation for spindle assembly: one molecule at a time.Trends in biochemical sciences · 2023Review
- The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes.Molecular biology of the cell · 2023Article
- Microtubule nucleation by γ-tubulin complexes and beyond.Essays in biochemistry · 2018Review
- γ-Tubulin⁻γ-Tubulin Interactions as the Basis for the Formation of a Meshwork.International journal of molecular sciences · 2018Review
- Metaphase Spindle Assembly.Biology · 2017Review
- γ-Tubulin complexes in microtubule nucleation and beyond.Molecular biology of the cell · 2015Article
- Identification and characterisation of structural maintenance of chromosome 1 (smc1) mutants of Coprinopsis cinerea.Molecular genetics and genomics : MGG · 2008Article
- Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans.Genetics · 2007Article
- gamma-tubulin plays an essential role in the coordination of mitotic events.Molecular biology of the cell · 2004Article
- GCP5 and GCP6: two new members of the human gamma-tubulin complex.Molecular biology of the cell · 2001Article
- Alanine-scanning mutagenesis of Aspergillus gamma-tubulin yields diverse and novel phenotypes.Molecular biology of the cell · 2001Article
- Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation.The EMBO journal · 1998Article
- Xgrip109: a gamma tubulin-associated protein with an essential role in gamma tubulin ring complex (gammaTuRC) assembly and centrosome function.The Journal of cell biology · 1998Article
- Spc98p directs the yeast gamma-tubulin complex into the nucleus and is subject to cell cycle-dependent phosphorylation on the nuclear side of the spindle pole body.Molecular biology of the cell · 1998Article
- Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p.The EMBO journal · 1997Article
- Essential role for gamma-tubulin in the acentriolar female meiotic spindle of Drosophila.The EMBO journal · 1997Article
- The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication.The EMBO journal · 1997Article
- Article
- The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.The EMBO journal · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We identified four mutations in two previously undescribed loci involved in microtubule function in Aspergillus nidulans as extragenic suppressors of benA33, a heat-sensitive beta-tubulin mutation. Three of the four mutations map to a locus closely linked to riboB on linkage group VIII; we designated this locus mipA (for microtubule-interacting protein). We were not able to map the remaining suppressor because of chromosomal rearrangements. However, since it recombines with riboB at a significantly higher frequency than the mipA alleles, it is unlikely to be in mipA; thus, we designated it mipB1. The mip mutations are not allelic to the previously identified loci that encode alpha- and beta-tubulin, and it is likely that mipA and mipB encode previously unidentified nontubulin proteins involved in microtubule function. Each of the mip mutations suppresses the heat sensitivity conferred by benA33 and suppresses the blockage of nuclear division and movement conferred by this mutation at high temperatures. Interactions between mipA and benA are allele specific. All of the mipA mutations are cryptic in a wild-type benA background but cause cold sensitivity in combination with benA33. These mutations also confer cold sensitivity in combination with benA31 and benA32 and reduce the resistance conferred by these mutations to the antimicrotubule agent benomyl but do not suppress the heat sensitivity conferred by these alleles. Finally, the mipA alleles suppress the heat sensitivity conferred by benA11, benA17, and benA21 but do not confer cold sensitivity in combination with these alleles.
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