Evidence map›Paper›PMID 35377216›Full record

ArticleMicrobiology spectrum2022

An Outer Membrane Protein YiaD Contributes to Adaptive Resistance of Meropenem in Acinetobacter baumannii.

Lei Han, Yiyuan Gao, Yuqing Liu, Siyu Yao, Shuyan Zhong, Sirui Zhang, Jingdan Wang, Peng Mi, Yurong Wen, Zhenlin Ouyang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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  15. The role of type VI secretion system genes in antibiotic resistance and virulence inFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Lei HanDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.ORCID 0000-0002-0900-1734
Yiyuan GaoDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yuqing LiuDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Siyu YaoDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Shuyan ZhongDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Sirui ZhangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Jingdan WangSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Peng MiDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yurong WenThe First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zhenlin OuyangThe First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jing ZhangDepartment of Laboratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Mona Mohamed Al-ShamiriDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Pu LiSchool of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Shaoshan HanDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xi'an Jiaotong University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acinetobacter baumannii is an important nosocomial pathogen that can develop various resistance mechanisms to many antibiotics. However, little is known about how it evolves from an antibiotic sensitive to a resistant phenotype. In this study, we investigated the transition of outer membrane proteins (OMPs) under antibiotic stress and identified YiaD as an OMP marker involved in the development of adaptive resistance to meropenem (MEM) in A. baumannii. Following stimulation of a carbapenem-sensitive strain AB5116 with sub-MIC of MEM,

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsMembrane ProteinsMeropenemMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsMembrane ProteinsMeropenemAcinetobacter baumanniiadaptive resistancemeropenemresistance evolutionYiaD

Identifiers

PMID35377216
PMCPMC9045393
OpenAlexW4225092844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.