Evidence map›Paper›PMID 35377180›Full record

ArticleJournal of the American Heart Association2022

Outcomes of Venoarterial Extracorporeal Membrane Oxygenation Plus Intra-Aortic Balloon Pumping for Treatment of Acute Myocardial Infarction Complicated by Cardiogenic Shock.

Takeshi Nishi, Masanobu Ishii, Kenichi Tsujita, Hiroshi Okamoto, Satoshi Koto, Michikazu Nakai, Yoko Sumita, Yoshitaka Iwanaga, Satoaki Matoba, Yoshio Kobayashi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  10. Cardiogenic Shock: Clinical Management, Outcomes and Future Directions.Journal of cardiovascular development and disease · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Takeshi NishiDepartment of Cardiology Kawasaki Medical School Kurashiki Okayama Japan.ORCID 0000-0002-5503-4692
Masanobu IshiiDepartment of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto City Japan.
Kenichi TsujitaDepartment of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto City Japan.
Hiroshi OkamotoDepartment of Cardiology Kawasaki Medical School Kurashiki Okayama Japan.
Satoshi KotoDepartment of Cardiology Kawasaki Medical School Kurashiki Okayama Japan.
Michikazu NakaiNational Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0003-2240-1510
Yoko SumitaNational Cerebral and Cardiovascular Center Suita Japan.ORCID 0000-0002-1424-145X
Yoshitaka IwanagaNational Cerebral and Cardiovascular Center Suita Japan.
Satoaki MatobaDepartment of Cardiovascular Medicine Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan.
Yoshio KobayashiDepartment of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba Japan.
Ken-Ichi HirataDivision of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Japan.
Yutaka HikichiDepartment of Cardiology Saga-Ken Medical Centre Koseikan Saga Japan.
Hiroyoshi YokoiCardiovascular Center Fukuoka Sanno Hospital Fukuoka Japan.
Yuji IkariDepartment of Cardiovascular Medicine Tokai University School of Medicine Isehara Japan.ORCID 0000-0001-5686-4324
Shiro UemuraDepartment of Cardiology Kawasaki Medical School Kurashiki Okayama Japan.ORCID 0000-0002-6089-5358
Kawasaki Medical School · JPNational Cerebral and Cardiovascular Center · JPKumamoto University · JPKobe University · JPKyoto Prefectural University of Medicine · JPObayashi (Japan) · JPSaga-Ken Medical Centre Koseikan · JPTokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Clinical outcomes of acute myocardial infarction complicated by cardiogenic shock remain poor with high in-hospital mortality. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used for patients with acute myocardial infarction complicated by cardiogenic shock refractory to conservative therapy, which is likely fatal without mechanical circulatory support. However, whether additional intra-aortic balloon pumping (IABP) use during VA-ECMO support improves clinical outcomes remains controversial. This study sought to investigate prognostic impact of the combined VA-ECMO plus IABP treatment compared with VA-ECMO alone. Methods and Results From the nationwide Japanese administrative case-mix Diagnostic Procedure Combination (DPC), the JROAD (Japanese Registry of All Cardiac and Vascular Diseases)-DPC, we identified 3815 patients with acute myocardial infarction complicated by cardiogenic shock who underwent primary percutaneous coronary intervention and managed with VA-ECMO. Of these, 2964 patients (77.7%) were managed with IABP (VA-ECMO plus IABP), whereas 851 (22.3%) were managed without IABP (VA-ECMO alone). We compared in-hospital, 7-day, and 30-day mortality between the VA-ECMO plus IABP versus the VA-ECMO alone support. Patients managed with VA-ECMO plus IABP demonstrated significantly lower in-hospital, 7-day, and 30-day mortality than those managed with VA-ECMO alone (adjusted odds ratios [95% CI] of 0.47 [95% CI, 0.38-0.59], 0.41 [95% CI, 0.33-0.51], and 0.30 [95% CI, 0.25-0.37], respectively). The findings were consistent in the propensity matching and inverse probability of treatment-weighting models. Conclusions This large-scale, nationwide study demonstrated that the combination of VA-ECMO plus IABP support was associated with significantly lower mortality compared with VA-ECMO support alone in patients presenting with acute myocardial infarction complicated by cardiogenic shock who underwent primary percutaneous coronary intervention.

Indexed as

Extracorporeal Membrane OxygenationMyocardial InfarctionPercutaneous Coronary InterventionHumansIntra-Aortic Balloon PumpingShock, CardiogenicTreatment Outcomeacute myocardial infarctioncardiogenic shockintra‐aortic balloon pumpingvenoarterial extracorporeal membrane oxygenation

Identifiers

PMID35377180
PMCPMC9075437
OpenAlexW4225335677

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.