ArticleEnvironmental monitoring and assessment2022
Determination of 15 human pharmaceutical residues in fish and shrimp tissues by high-performance liquid chromatography-tandem mass spectrometry.
Article in Environmental monitoring and assessment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Acute and Chronic Toxicity of Ketoprofen Active Pharmaceutical Ingredient and Commercial Formulations to the Freshwater Photosynthetic SpeciesInternational journal of environmental research and public health · 2026Article
- The Hidden Threat of Pharmaceuticals: Ketoprofen Degradation and Toxicity to Non-Target Organisms.Molecules (Basel, Switzerland) · 2026Review
- HPLC and CE Procedures for the Determination of Fluoroquinolones (2020-2025).Molecules (Basel, Switzerland) · 2026Review
- Development and Validation of QuEChERS Extraction Coupled with Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry for the Detection of Nine Macrolides in Fish Products.Foods (Basel, Switzerland) · 2025Article
- Dispersive Solid-Phase Extraction and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry-A Rapid and Accurate Method for Detecting 10 Macrolide Residues in Aquatic Products.Foods (Basel, Switzerland) · 2024Article
- Integrated microfluidic systems for fluorescence monitoring rapid kinetic reactions in bioanalysis.Mikrochimica acta · 2023Article
- Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal.Frontiers in microbiology · 2023Review
- An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms.Molecules (Basel, Switzerland) · 2022Review
- Degradation of Triclosan in the Water Environment by Microorganisms: A Review.Microorganisms · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An efficient, reliable, and sensitive multiclass analytical method has been expanded to simultaneously determine 15 human pharmaceutical residues in fish and shrimp tissue samples by ultra-high-performance liquid chromatography-tandem mass spectrometry. The investigated compounds comprise ten classes, namely, analgesic, antibacterial, anticonvulsant, cardiovascular, fluoroquinolones, macrolides, nonsteroidal anti-inflammatory, penicillins, stimulant, and sulfonamide. A simple liquid extraction procedure based on 0.1% formic acid in methanol was developed. Chromatographic conditions were optimized, and mobile phase A was 0.1% ammonium acetate, and mobile phase B was acetonitrile. The mobile phase's gradient program was as follows: 0-2 min, 15% B; 2-5 min, linear to 95% B; 5-10 min, 95% B; and 10-12 min. The limits of detection were from 0.017 to 1.371 μg/kg, while a quantification range was measured from 0.051 to 4.113 μg/kg. Finally, amoxicillin, azithromycin, caffeine, carbamazepine, ciprofloxacin, clarithromycin, diclofenac, erythromycin, furosemide, ibuprofen, ketoprofen, naproxen, sulfamethoxazole, tetracycline, and triclosan were quantifiable in fish and shrimp samples.
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