ArticlePediatric blood & cancer2022
Regional anesthesia for sickle cell disease vaso-occlusive crisis: A single-center case series.
Article in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pain Control for Sickle Cell Crisis, a Novel Approach? A Retrospective Study.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Beyond IV push: alternative methods for management of acute pain in SCD.Hematology. American Society of Hematology. Education Program · 2024Review
- Single-centre case series report of regional anaesthesia for pain management in vaso-occlusive crisis.Indian journal of anaesthesia · 2024Article
- Regional anesthesia and analgesia in sickle cell pain episodes: A scoping review.Interventional pain medicine · 2022Article
- Novel use of genicular and vastus intermedius blocks for refractory knee pain in sickle cell disease.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pain management is challenging for patients with sickle cell disease (SCD) who present in vaso-occlusive crisis (VOC). Opioid therapy is highly effective, nevertheless undesirable side effects can hinder their effectiveness. Regional anesthesia with deposition of perineural anesthetic offers nociceptive blockade, local vasodilatation, and reduces the inflammatory response. Among pediatric patients, continuous peripheral nerve block (CPNB) for perioperative adjunctive analgesia is safe. Herein, we describe the trajectory of a cohort of pediatric SCD patients with opioid-refractory upper-extremity VOC following placement of CPNBs for analgesia; highlighting reduced opioid consumption, improved pain scores, and decreased length of hospitalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.