ArticleJournal of radiation research2022
Quantifying the dosimetric effects of neck contour changes and setup errors on the spinal cord in patients with nasopharyngeal carcinoma: establishing a rapid estimation method.
Article in Journal of radiation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- The impact of orthogonal image-guided frequency on positioning error correction and dose in postoperative radiotherapy for breast cancer.BMC cancer · 2026Article
- Positioning accuracy and dosimetric evaluation of customized immobilization for FBCT guided VMAT in nasopharyngeal carcinoma.Scientific reports · 2025Article
- Review
- Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy.Technology in cancer research & treatmentArticle
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The purpose of this study was to quantify the effect of neck contour changes and setup errors on spinal cord (SC) doses during the treatment of nasopharyngeal carcinoma (NPC) and to establish a rapid dose estimation method. The setup errors and contour changes in 60 cone-beam computed tomography (CBCT) images of 10 NPC patients were analysed in different regions of the neck (C1-C3, C4-C5 and C6-C7). The actual delivered dose to the SC was calculated using the CBCT images, and univariate simulations were performed using the planning CT to evaluate the dose effects of each factor, and an index ${\mathrm{Dmax}}_{\mathrm{displaced}}$ was introduced to estimate the SC dose. Compared with the planned dose, the mean (maximum) Dmax increases in the C1-C3, C4-C5 and C6-C7 regions of the SC were 2.1% (12.3%), 1.8% (8.2%) and 2.5% (9.2%), respectively. The simulation results showed that the effects of setup error in the C1-C3, C4-C5 and C6-C7 regions were 1.5% (9.7%), 0.9% (8.2%) and 1.3% (6.3%), respectively, and the effects of contour change were 0.4% (1.7%), 0.7% (2.5%) and 1.5% (4.9%), respectively. The linear regression model can be used to estimate the dose effect of contour changes (R2 > 0.975) and setup errors (R2 = 0.989). Setup errors may lead to a significant increase in the SC dose in some patients. This study established a rapid dose estimation method, which is of great significance for the daily dose evaluation and the adaptive re-planning trigger of the SC.
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Registered trials
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