ArticleInternational journal of stroke : official journal of the International Stroke Society2023
Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke.
Article in International journal of stroke : official journal of the International Stroke Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Neuroimaging predictors of malignant brain oedema after thrombectomy in ischemic stroke: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Risk prediction models for malignant cerebral edema after endovascular therapy in patients with acute anterior circulation large vessel occlusion stroke: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Cerebrospinal fluid-based clinical-radiomics model for predicting treatment prognosis of acute ischemic stroke.Quantitative imaging in medicine and surgery · 2025Article
- Automatic measurement and reference values setting of intracranial cerebrospinal fluid volume: a large-scale analysis of computed tomography images.Quantitative imaging in medicine and surgery · 2025Article
- Brain fluid physiology in ischaemic stroke; more than just oedema.Fluids and barriers of the CNS · 2025Review
- Early automated cerebral edema assessment following endovascular therapy: impact on stroke outcome.Journal of neurointerventional surgery · 2025Article
- Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke.Journal of cardiovascular development and disease · 2024Article
- Novel advanced imaging techniques for cerebral oedema.Frontiers in neurology · 2024Review
- Intracranial pressure elevation post-stroke: Mechanisms and consequences.Frontiers in stroke · 2023Review
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Authors and funding
13 authors at 6 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ratio of intracranial cerebrospinal fluid (CSF) volume to intracranial volume (ICV) has been identified as a potential predictor of malignant edema formation in patients with acute ischemic stroke.
aimsWe aimed to evaluate the added value of the CSF/ICV ratio in a model to predict malignant edema formation in patients who underwent endovascular treatment.
methodsWe included patients from the MR CLEAN Registry, a prospective national multicenter registry of patients who were treated with endovascular treatment between 2014 and 2017 because of acute ischemic stroke caused by large vessel occlusion. The CSF/ICV ratio was automatically measured on baseline thin-slice noncontrast CT. The primary outcome was the occurrence of malignant edema based on clinical and imaging features. The basic model included the following predictors: age, National Institutes of Health Stroke Scale, Alberta Stroke Program Early CT score, occlusion of the internal carotid artery, collateral score, time between symptom onset and groin puncture, and unsuccessful reperfusion. The extended model included the basic model and the CSF/ICV ratio. The performance of the basic and the extended model was compared with the likelihood ratio test.
resultsMalignant edema occurred in 40 (6%) of 683 patients. In the extended model, a lower CSF/ICV ratio was associated with the occurrence of malignant edema (odds ratio (OR) per percentage point, 1.2; 95% confidence interval (CI) 1.1-1.3,
conclusionsAdding the CSF/ICV ratio improves a multimodal prediction model for the occurrence of malignant edema after endovascular treatment.
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