Evidence map›Paper›PMID 35373606›Full record

ArticleThe American journal of sports medicine2022

Meniscal Treatment as a Predictor of Worse Articular Cartilage Damage on MRI at 2 Years After ACL Reconstruction: The MOON Nested Cohort.

Faysal F Altahawi, Emily K Reinke, MOON Knee Group, Isaac Briskin, William A Cantrell, David C Flanigan, Braden C Fleming, Laura J Huston, Xiaojuan Li, Sameer R Oak and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Associations Between Patient Characteristics and Cartilage T1ρ Relaxation Times Vary Over Time Following Patellar Dislocation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Teaming up to overcome challenges toward translation of new therapeutics for osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Faysal F AltahawiInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Emily K ReinkeInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
MOON Knee GroupInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Isaac BriskinInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
William A CantrellInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
David C FlaniganInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Braden C FlemingInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Laura J HustonInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Xiaojuan LiInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Sameer R OakInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Nancy A ObuchowskiInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Erica A ScaramuzzaInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Carl S WinalskiInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Alex ZajichekInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Kurt P SpindlerInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.
Morgan H JonesInvestigation performed at the Cleveland Clinic, Cleveland, Ohio, USA and Venderbilt Medical Center, Nashville, Tennessee.

Funding

Prognosis and Predictors of ACL Reconstruction: A Multicenter Cohort StudyR01AR053684 · NIAMS · VANDERBILT UNIVERSITY · PI SPINDLER, KURT PAUL · 2006 to 2020
$8.3M
Meniscus status and activity level after ACLK23AR066133 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI JONES, MORGAN HERANCOURT · 2015 to 2019
$745k
NIAMS NIH HHS K23 AR066133NIAMS NIH HHS R01 AR053684
6 · The paper itself

Abstract

backgroundPatients undergoing anterior cruciate ligament reconstruction (ACLR) are at an increased risk for posttraumatic osteoarthritis (PTOA). While we have previously shown that meniscal treatment with ACLR predicts more radiographic PTOA at 2 to 3 years postoperatively, there are a limited number of similar studies that have assessed cartilage directly with magnetic resonance imaging (MRI). HYPOTHESIS: Meniscal repair or partial meniscectomy at the time of ACLR independently predicts more articular cartilage damage on 2- to 3-year postoperative MRI compared with a healthy meniscus or a stable untreated tear. STUDY

designCohort study; Level of evidence, 2.

methodsA consecutive series of patients undergoing ACLR from 1 site within the prospective, nested Multicenter Orthopaedic Outcomes Network (MOON) cohort underwent bilateral knee MRI at 2 to 3 years postoperatively. Patients were aged <36 years without previous knee injuries, were injured while playing sports, and had no history of concomitant ligament surgery or contralateral knee surgery. MRI scans were graded by a board-certified musculoskeletal radiologist using the modified MRI Osteoarthritis Knee Score (MOAKS). A proportional odds logistic regression model was built to predict a MOAKS-based cartilage damage score (CDS) relative to the contralateral control knee for each compartment as well as for the whole knee, pooled by meniscal treatment, while controlling for sex, age, body mass index, baseline Marx activity score, and baseline operative cartilage grade. For analysis, meniscal injuries surgically treated with partial meniscectomy or meniscal repair were grouped together.

resultsThe cohort included 60 patients (32 female; median age, 18.7 years). Concomitant meniscal treatment at the time of index ACLR was performed in 17 medial menisci (13 meniscal repair and 4 partial meniscectomy) and 27 lateral menisci (3 meniscal repair and 24 partial meniscectomy). Articular cartilage damage was worse in the ipsilateral reconstructed knee (

conclusionA meniscal injury requiring surgical treatment with partial meniscectomy or meniscal repair at the time of ACLR predicted worse articular cartilage damage on MRI at 2 to 3 years after surgery. Further research is required to differentiate between the effects of partial meniscectomy and meniscal repair.

Indexed as

Anterior Cruciate Ligament InjuriesCartilage, ArticularMeniscusOrthopedicsAdolescentAdultCohort StudiesFemaleHumansMagnetic Resonance ImagingProspective Studiesanterior cruciate ligament reconstructionmeniscusMRIposttraumatic osteoarthritis

Identifiers

PMID35373606
PMCPMC9176689

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.