Evidence map›Paper›PMID 35373509›Full record

Observational studyAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2022

Challenges encountered in conducting donor-based research: Lessons learned from the Donor Heart Study.

Kiran K Khush, Helen Luikart, Nikole Neidlinger, Ahmad Salehi, John Nguyen, P J Geraghty, John Belcher, Bruce Nicely, Martin Jendrisak, Thomas Pearson and 5 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Reasons for donor heart offer refusal are often unrelated to the donor itself - when, why, and the "weekend effect".The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025
    Observational
  2. Reasons for donor heart offer refusal in the United States: Results from 14,132 transplant clinician surveys in the Donor Heart Study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025
    Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Kiran K KhushDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.ORCID 0000-0001-9697-5926
Helen LuikartDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.
Nikole NeidlingerDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0003-3012-5077
Ahmad SalehiDonor Network West, San Ramon, California.
John NguyenDivision of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco.
P J GeraghtyDonor Network of Arizona, Tempe, Arizona.
John BelcherNew England Donor Services, Waltham, Massachusetts.
Bruce NicelyGift of Life Michigan, Ann Arbor, Michigan.
Martin JendrisakGift of Hope Organ and Tissue Donor Network, Itasca, Illinois.
Thomas PearsonLifeLink Foundation, Norcross, Georgia.
R Patrick WoodLifeGift Organ Donation Center, Houston, Texas.
Tahnee GroatDepartment of Surgery, Division of Trauma, Critical Care, and Acute Care Surgery, Oregon Health and Science University, Portland, Oregon.
Brian WaydaDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.ORCID 0000-0001-7005-9938
Jonathan G ZaroffDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Darren MalinoskiDepartment of Surgery, Division of Trauma, Critical Care, and Acute Care Surgery, Oregon Health and Science University, Portland, Oregon.
Stanford University · USDonor Network West · USOregon Health & Science University · USGift of Hope Organ and Tissue Donor Network · USGift of Life Michigan · USKaiser Permanente · USLink Foundation · USNational Marrow Donor Program · USNew England Organ Bank · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · US

Funding

Evidence Based Evaluation and Acceptance of Donor Hearts for TransplantationR01HL125303 · NHLBI · STANFORD UNIVERSITY · PI KHUSH, KIRAN KAUR · 2015 to 2019
$3.0M
Narrowing the gap between supply and demand in heart transplantationF32HL154750 · NHLBI · STANFORD UNIVERSITY · PI WAYDA, BRIAN · 2022 to 2024
$165k
NHLBI NIH HHS F32 HL154750NHLBI NIH HHS R01 HL125303
6 · The paper itself

Abstract

Solid organ transplantation continues to be constrained by a lack of suitable donor organs. Advances in donor management and evaluation are needed to address this shortage, but the performance of research studies in deceased donors is fraught with challenges. Here we discuss several of the major obstacles we faced in the conduct of the Donor Heart Study-a prospective, multi-site, observational study of donor management, evaluation, and acceptance for heart transplantation. These included recruitment and engagement of participating organ procurement organizations, ambiguities related to study oversight, obtaining authorization for donor research, logistical challenges encountered during donor management, sustaining study momentum, and challenges related to study data management. By highlighting these obstacles encountered, as well as the solutions implemented, we hope to stimulate further discussion and actions that will facilitate the design and execution of future donor research studies.

Indexed as

Heart TransplantationOrgan TransplantationTissue and Organ ProcurementHumansProspective StudiesTissue Donorsclinical research/practicedonor evaluationdonors and donationeditorial/personal viewpointethicsheart transplantation/cardiologyorgan procurement and allocation

Identifiers

PMID35373509
PMCPMC9262765
OpenAlexW4223994805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.