Evidence map›Paper›PMID 35373498›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.

Akihiko Ito, Mitsuo Hashimoto, Jun Tanihata, Sachi Matsubayashi, Ryoko Sasaki, Shota Fujimoto, Hironori Kawamoto, Yusuke Hosaka, Akihiro Ichikawa, Tsukasa Kadota and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. β2-Microglobulin Induces Mitochondrial Dysfunction Accompanied by Bronchial Epithelial Cell Senescence.International journal of chronic obstructive pulmonary disease · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Akihiko ItoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Mitsuo HashimotoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.ORCID 0000-0002-4817-2210
Jun TanihataDepartment of Cell Physiology, The Jikei University, Tokyo, Japan.
Sachi MatsubayashiDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Ryoko SasakiDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Shota FujimotoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Hironori KawamotoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Yusuke HosakaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Akihiro IchikawaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Tsukasa KadotaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Yu FujitaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Daisuke TakekoshiDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Sabro ItoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Shunsuke MinagawaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Takanori NumataDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Hiromichi HaraDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Tatsuki MatsuokaDepartment of Orthopedic Surgery, The Jikei University, Tokyo, Japan.
Jun UdakaDepartment of Orthopedic Surgery, The Jikei University, Tokyo, Japan.
Jun ArayaDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Mitsuru SaitoDepartment of Orthopedic Surgery, The Jikei University, Tokyo, Japan.
Kazuyoshi KuwanoDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University, Tokyo, Japan.
Jikei University School of Medicine · JP

Funding

GSK Japan Research Grant 2018JSPS KAKENHI Grant
6 · The paper itself

Abstract

backgroundSarcopenia is characterized by the loss of skeletal muscle mass and strength and is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) exposure, a major cause for COPD, induces mitochondrial damage, which has been implicated in sarcopenia pathogenesis. The current study sought to examine the involvement of insufficient Parkin-mediated mitophagy, a mitochondrion-selective autophagy, in the mechanisms by which dysfunctional mitochondria accumulate with excessive reactive oxygen species (ROS) production in the development of COPD-related sarcopenia.

methodsThe involvement of Parkin-mediated mitophagy was examined using in vitro models of myotube formation, in vivo CS-exposure model using Parkin

resultsCigarette smoke extract (CSE) induced myotube atrophy with concomitant 30% reduction in Parkin expression levels (P < 0.05). Parkin-mediated mitophagy regulated myotube atrophy by modulating mitochondrial damage and mitochondrial ROS production. Increased mitochondrial ROS was responsible for myotube atrophy by activating Muscle Ring Finger 1 (MuRF-1)-mediated myosin heavy chain (MHC) degradation. Parkin

conclusionsTaken together, COPD-related sarcopenia can be attributed to insufficient Parkin-mediated mitophagy and increased mitochondrial ROS causing enhanced muscle atrophy through MuRF-1 activation, which may be at least partly preventable through optimal physical exercise.

Indexed as

Pulmonary Disease, Chronic ObstructiveSarcopeniaUbiquitin-Protein LigasesAnimalsHumansMiceMice, Inbred C57BLMitophagyMuscular AtrophyReactive Oxygen Speciesparkin proteinReactive Oxygen SpeciesUbiquitin-Protein LigasesCigarette smokeCOPDMuscle atrophyMuscle contractionParkin

Identifiers

PMID35373498
PMCPMC9178376
OpenAlexW4224030994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.