Evidence map›Paper›PMID 35373215›Full record

ArticleFaculty reviews2022

Proteolytic regulation of calcium channels - avoiding controversy.

Bruce Alberts, Roger J Colbran, Annette C Dolphin, Geoffrey S Pitt, Thomas C Südhof

Abstract readComment
In one paragraph

Article in Faculty reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bruce AlbertsUniversity of California San Francisco.ORCID https://orcid.org/0000-0002-2267-3754
Roger J ColbranVanderbilt University.ORCID https://orcid.org/0000-0001-7401-8244
Annette C DolphinUniversity College London.ORCID https://orcid.org/0000-0003-4626-4856
Geoffrey S PittWeill Cornell Medicine.ORCID https://orcid.org/0000-0003-2246-0289
Thomas C SüdhofStanford University.ORCID https://orcid.org/0000-0003-3361-9275

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The publication of papers containing data obtained with suboptimal rigor in the experimental design and choice of key reagents, such as antibodies, can result in a lack of reproducibility and generate controversy that can both needlessly divert resources and, in some cases, damage public perception of the scientific enterprise. This exemplary paper by Buonarati

Indexed as

CalciumCalcium channelsCav1.2C-terminal

Identifiers

PMID35373215
PMCPMC8958896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.