ArticleJACS Au2022
Controlled Intracellular Polymerization for Cancer Treatment.
Article in JACS Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization.Nature communications · 2025Article
- Bacteria-Mediated Intracellular Radical Polymerizations.Journal of the American Chemical Society · 2025Article
- Hypoxia-Initiated Supramolecular Free Radicals Induce Intracellular Polymerization for Precision Tumor Therapy.Journal of the American Chemical Society · 2025Article
- Light-Controlled Intracellular Synthesis of Poly(luciferin) Polymers Induces Cell Paraptosis.Journal of the American Chemical Society · 2025Article
- Catalyzing PET-RAFT Polymerizations Using Inherently Photoactive Zinc Myoglobin.Angewandte Chemie (International ed. in English) · 2025Article
- Choline Carboxylic Acid Ionic Liquid-stabilized Anisotropic Gold Nanoparticles for Photothermal Therapy.ACS applied nano materials · 2024Article
- Precise Regulations at the Subcellular Level through Intracellular Polymerization, Assembly, and Transformation.JACS Au · 2024Review
- Applications of synthetic polymers directed toward living cells.Nature synthesis · 2024Article
- Light-mediated intracellular polymerization.Nature protocols · 2024Article
- Site-selected in situ polymerization for living cell surface engineering.Nature communications · 2023Article
- Genetically targeted chemical assembly of polymers specifically localized extracellularly to surface membranes of living neurons.Science advances · 2023Article
- Tyrosine residues initiated photopolymerization in living organisms.Nature communications · 2023Article
- Article
- Polymer Chemistry in Living Cells.Accounts of chemical research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization. This unique polymerization process provided a platform for the synthesis of structure-predictable polymers with well-defined structures in living cells. The intracellularly generated poly(
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.