ArticleJACS Au2022
Mapping out the Aqueous Surface Chemistry of Metal Oxide Nanocrystals: Carboxylate, Phosphonate, and Catecholate Ligands.
Article in JACS Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Contrast-enhanced micro-computed tomography visualization of adhesively bonded CFRP/aluminum tubular joints.Nanoscale advances · 2026Article
- Occurrence, Stabilization, and Emerging Functions of the Early-Transition Metal Oxyanions Including Polyoxometalates in Various Complex Structures.Chemistry, an Asian journal · 2026Review
- Coordination chemistry-enabled drug delivery systems: metal-ligand platforms for controlled release and targeted therapeutics.Journal of nanobiotechnology · 2026Review
- Magnetic Iron Oxide Nanoparticles: Advances in Synthesis, Mechanistic Understanding, and Magnetic Property Optimization for Improved Biomedical Performance.Nanomaterials (Basel, Switzerland) · 2025Review
- Prospects of Nanoscience with Nanocrystals: 2025 Edition.ACS nano · 2025Review
- Morphology Effect of PEGylated Iron Oxide Nanoparticles on the Enhancement of MRI Contrast Signal in Breast Cancer.ACS applied materials & interfaces · 2025Article
- Ligand-Dependent Optical Properties of Colloidal Ternary Spinel Oxide Nanocrystals Containing Transition Metals.Inorganic chemistry · 2025Article
- Expanding the Design Space of Polymer-Metal Organic Framework (MOF) Gels by Understanding Polymer-MOF Interactions.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Synthesis of zirconium(IV) and hafnium(IV) isopropoxide,Dalton transactions (Cambridge, England : 2003) · 2024Article
- Surface Adsorption and Photoinduced Degradation: A Study of Spinel Ferrite Nanomaterials for Removal of a Model Organic Pollutant from Water.Chemistry of materials : a publication of the American Chemical Society · 2024Review
- From Gel to Crystal: Mechanism of HfOJournal of the American Chemical Society · 2024Article
- Fatty acid capped, metal oxo clusters as the smallest conceivable nanocrystal prototypes.Chemical science · 2023Article
- Solution-Processed Inorganic Thermoelectric Materials: Opportunities and Challenges.Chemistry of materials : a publication of the American Chemical Society · 2022Review
- Mechanistic Insight into the Precursor Chemistry of ZrOJACS Au · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron oxide and hafnium oxide nanocrystals are two of the few successful examples of inorganic nanocrystals used in a clinical setting. Although crucial to their application, their aqueous surface chemistry is not fully understood. The literature contains conflicting reports regarding the optimum binding group. To alleviate these inconsistencies, we set out to systematically investigate the interaction of carboxylic acids, phosphonic acids, and catechols to metal oxide nanocrystals in polar media. Using nuclear magnetic resonance spectroscopy and dynamic light scattering, we map out the pH-dependent binding affinity of the ligands toward hafnium oxide nanocrystals (an NMR-compatible model system). Carboxylic acids easily desorb in water from the surface and only provide limited colloidal stability from pH 2 to pH 6. Phosphonic acids, on the other hand, provide colloidal stability over a broader pH range but also feature a pH-dependent desorption from the surface. They are most suited for acidic to neutral environments (pH <8). Finally, nitrocatechol derivatives provide a tightly bound ligand shell and colloidal stability at physiological and basic pH (6-10). Whereas dynamically bound ligands (carboxylates and phosphonates) do not provide colloidal stability in phosphate-buffered saline, the tightly bound nitrocatechols provide long-term stability. We thus shed light on the complex ligand binding dynamics on metal oxide nanocrystals in aqueous environments. Finally, we provide a practical colloidal stability map, guiding researchers to rationally design ligands for their desired application.
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Registered trials
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