Evidence map›Paper›PMID 35373067›Full record

ArticleKidney3602021

Renal Recovery and Mortality Risk among Patients with Hepatorenal Syndrome Receiving Chronic Maintenance Dialysis.

Sophie McAllister, Jennifer C Lai, Timothy P Copeland, Kirsten L Johansen, Charles E McCulloch, Yuenting D Kwong, Divya Seth, Barbara Grimes, Elaine Ku

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney360, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sophie McAllisterSchool of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0003-1024-0027
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, California.
Timothy P CopelandDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California.
Kirsten L JohansenDivision of Nephrology, Department of Medicine, Hennepin Healthcare and University of Minnesota, Minneapolis, Minnesota.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Yuenting D KwongDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California.
Divya SethDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California.
Barbara GrimesDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Elaine KuDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USUniversity of Minnesota · US

Funding

The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
Blood pressure trends, outcomes, and interventions in adolescents and young adults at increased cardiovascular riskK23HL131023 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KU, ELAINE · 2016 to 2020
$991k
Identification of Sub-phenotypes in Sepsis Associated Acute Kidney InjuryF32DK118870 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KWONG, YUENTING DIANA · 2018 to 2020
$163k
NHLBI NIH HHS K23 HL131023NIA NIH HHS R01 AG059183NIDDK NIH HHS F32 DK118870
6 · The paper itself

Abstract

Background: Kidney replacement therapy is controversial for patients with hepatorenal syndrome who may not be liver transplant candidates. Data surrounding the likelihood of recovery of kidney function and mortality after outpatient dialysis initiation in patients with dialysis-requiring hepatorenal syndrome could inform discussions between patients and providers. Methods: We performed a retrospective cohort study of patients with hepatorenal syndrome who were registered in the United States Renal Data System between 1996 and 2015 ( Results: Of the patients with hepatorenal syndrome, 11% recovered kidney function. Those with higher likelihood of recovery were younger, non-Hispanic White, and had a history of alcohol use. Compared with patients with acute tubular necrosis, patients with hepatorenal syndrome as the attributed cause of kidney disease had a lower hazard of recovery (HR, 0.22; 95% CI, 0.21 to 0.24) and higher hazard of death within 1 year (HR, 3.10; 95% CI, 2.99 to 3.23) in fully adjusted models. Conclusions: Patients with hepatorenal syndrome receiving chronic maintenance dialysis had a lower likelihood of recovery of kidney function and higher mortality risk compared with patients with acute tubular necrosis. Among patients with hepatorenal syndrome, those most likely to recover kidney function were younger, had a history of alcohol use, and lacked comorbid conditions. These data may inform prognosis and discussions surrounding treatment options when patients with hepatorenal syndrome need chronic maintenance dialysis therapy.

Indexed as

Hepatorenal SyndromeHumansKidneyRenal DialysisRenal Replacement TherapyRetrospective StudiesUnited Statesacute tubular necrosisdialysisend stage kidney diseasehemodialysishepatorenal syndromerenal failurerenal replacement therapyUnited States Renal Data System

Identifiers

PMID35373067
PMCPMC8791353
OpenAlexW3135643825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.