Evidence map›Paper›PMID 35372867›Full record

ArticleKidney3602020

Histopathologic and Clinical Features in Patients with Diabetes and Kidney Disease.

Sarah F Sanghavi, Travis Roark, Leila R Zelnick, Behzad Najafian, Nicole K Andeen, Charles E Alpers, Raimund Pichler, Ernest Ayers, Ian H de Boer

Open access · diamondAbstract read
In one paragraph

Article in Kidney360, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Diabetic Kidney Disease Prevention Care Model Development.Clinical diabetes : a publication of the American Diabetes Association · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sarah F SanghaviDivision of Nephrology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.ORCID 0000-0002-4808-910X
Travis RoarkDepartment of Internal Medicine, Scripps Clinic, Scripps Health, San Diego, California.
Leila R ZelnickDivision of Nephrology, Department of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington.
Behzad NajafianDepartment of Pathology, University of Washington, Seattle, Washington.
Nicole K AndeenDepartment of Pathology, Oregon Health & Science University, Portland, Oregon.
Charles E AlpersDepartment of Pathology, University of Washington, Seattle, Washington.
Raimund PichlerDivision of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
Ernest AyersDivision of Nephrology, Department of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington.
Ian H de BoerDivision of Nephrology, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
University of Washington · USOregon Health & Science University · USScripps Health · USVA Puget Sound Health Care System · US

Funding

Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney diseaseR01DK088762 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H · 2010 to 2019
$4.7M
NIDDK NIH HHS R01 DK088762
6 · The paper itself

Abstract

Background: The discovery of nondiabetic kidney disease (NDKD) in an individual patient with diabetes may have significant treatment implications. Extensive histopathologic data in this population are lacking, but they may provide insights into the complex pathogenesis of diabetic nephropathy (DN) and reveal specific phenotypes for the development of targeted therapies. This study seeks to elucidate the clinical and laboratory parameters associated with the spectrum of kidney histopathologic features in patients with diabetes. Methods: This study is a retrospective analysis of 399 kidney biopsies assessed from 2014 to 2016 at the University of Washington among patients with diabetes. More comprehensive clinical data were evaluated in a subset of 79 participants. Results: Of the 399 biopsies reviewed, 192 (48%) had a primary diagnosis of DN (including 26 with an additional diagnosis), and 207 (52%) had a primary diagnosis of NDKD (including 67 who also had DN). Retinopathy (sensitivity: 0.86; specificity: 0.81; OR, 27.1; 95% CI, 6.8 to 107.7) and higher levels of proteinuria (7.6 versus 4.1 g/d; Conclusions: Among patients with diabetes who undergo kidney biopsy in the Pacific Northwest, approximately half have DN, and half have NDKD. Retinopathy and more severe proteinuria were associated with DN, and AKI was a more common descriptor in NDKD.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesGlomerulonephritis, IGAHumansProteinuriaRetrospective Studiesdiabetes and the kidneydiabetes mellitusdiabetic kidney diseasediabetic retinopathyfocal segmental glomerulosclerosishistopathologyproteinuria

Identifiers

PMID35372867
PMCPMC8815499
OpenAlexW3085166735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.