ArticleCritical care explorations2022
Methods for Phenotyping Adult Patients in Sepsis and Septic Shock: A Scoping Review.
Article in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Telodendrimer nanotrap for selective cytokine removal from sepsis patient plasma.Frontiers in immunology · 2026Article
- Identification and Characterization of Sepsis Phenotypes in an Indian Cohort.Critical care research and practice · 2026Article
- Individualized treatment rule for early steroid use in hospitalized patients with community acquired pneumonia: a cohort study.Pneumonia (Nathan Qld.) · 2025Article
- Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure.Critical care (London, England) · 2025Observational
- Deciphering the impact of sepsis phenotypes on improving clinical outcome predictions: a multicenter retrospective analysis based on critical care in China.Scientific reports · 2025Article
- SepsisJournal of medical microbiology · 2025Review
- Resistin as a potential diagnostic biomarker for sepsis: insights from DIA and ELISA analyses.Clinical proteomics · 2024Article
- Review
- Clinical Sepsis Phenotypes in Critically Ill Patients.Microorganisms · 2023Review
- Clinical Phenotypes of Sepsis in a Cohort of Hospitalized Patients According to Infection Site.Critical care explorations · 2023Article
- Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response.Critical care explorations · 2023Article
- Redefying the therapeutic strategies against cardiorenal morbidity and mortality: Patient phenotypes.World journal of cardiology · 2023Review
- The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping andFrontiers in cellular and infection microbiology · 2023Review
- Identifying inflammatory phenotypes to target mechanism-specific treatments in sepsis.Cell reports. Medicine · 2022Article
- Bulk RNA Sequencing With Integrated Single-Cell RNA Sequencing Identifies BCL2A1 as a Potential Diagnostic and Prognostic Biomarker for Sepsis.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Despite its heterogeneous phenotypes, sepsis or life-threatening dysfunction in response to infection is often treated empirically. Identifying patient subgroups with unique pathophysiology and treatment response is critical to the advancement of sepsis care. However, phenotyping methods and results are as heterogeneous as the disease itself. This scoping review evaluates the prognostic capabilities and treatment implications of adult sepsis and septic shock phenotyping methods. DATA SOURCES: Medline and Embase. STUDY SELECTION: We included clinical studies that described sepsis or septic shock and used any clustering method to identify sepsis phenotypes. We excluded conference abstracts, literature reviews, comments, letters to the editor, and in vitro studies. We assessed study quality using a validated risk of bias tool for observational cohort and cross-sectional studies. DATA EXTRACTION: We extracted population, methodology, validation, and phenotyping characteristics from 17 studies. DATA SYNTHESIS: Sepsis phenotyping methods most frequently grouped patients based on the degree of inflammatory response and coagulopathy using clinical, nongenomic variables. Five articles clustered patients based on genomic or transcriptomic data. Seven articles generated patient subgroups with differential response to sepsis treatments. Cluster clinical characteristics and their associations with mortality and treatment response were heterogeneous across studies, and validity was evaluated in nine of 17 articles, hindering pooled analysis of results and derivation of universal truths regarding sepsis phenotypes, their prognostic capabilities, and their associations with treatment response.
conclusionsSepsis phenotyping methods can identify high-risk patients and those with high probability of responding well to targeted treatments. Research quality was fair, but achieving generalizability and clinical impact of sepsis phenotyping will require external validation and direct comparison with alternative approaches.
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