Evidence map›Paper›PMID 35372814›Full record

ArticleiScience2022

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

Gaojian Zhang, Jianxiong Han, Lili Wang, Xuegang Yang, Zhongkang Yan, Min Qu, Huijuan Zhou, Hazrat Bilal, Feifei Wang, Honghua Ge and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Gaojian ZhangInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Jianxiong HanInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Lili WangSchool of Life Science, Anhui University, Hefei, Anhui 230601, P.R. China.
Xuegang YangInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Zhongkang YanInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Min QuInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Huijuan ZhouInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Hazrat BilalInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Feifei WangInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Honghua GeInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Xingyuan YangInstitute of Physical Science and Information Technology, Institute of Health Sciences Anhui University, Hefei, Anhui 230601, P.R. China.
Anhui University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic lipid accumulation is closely associated with nonalcoholic fatty liver disease (NAFLD). Adipose-triglyceride-lipase (ATGL) regulates triglyceride hydrolysis and maintains energy homeostasis in hepatocytes. Identifying key factors in the regulation of ATGL will help tackle hepatic lipid accumulation and related metabolic diseases. Herein, we demonstrate that syntaxin11 (STX11), a member of the SNARE family, generally expressed in immune cells, mediates lipid metabolism by binding to ATGL and inhibiting lipid droplet degradation and lipid autophagy in hepatocytes. Our data show that the C-terminal of STX11 and the patatin domain-containing segment of ATGL have direct physical interactions. Thus, STX11 overexpression prevents spatial translocation of ATGL onto LDs by recruitment of ATGL to the ER. Conversely, STX11 deficiency in hepatocytes promotes lipid hydrolysis, and the ATGL-SIRT1 signaling pathway enhances lipophagy. Overall, this study uncovered that the regulation of lipolysis and lipophagy is achieved by STX11 through the attenuation of ATGL action in hepatocytes.

Indexed as

Biological sciencesCell biologyEndocrinologyMolecular biologyPhysiology

Identifiers

PMID35372814
PMCPMC8971941
OpenAlexW4220683273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.