Evidence map›Paper›PMID 35372700›Full record

ArticleWellcome open research2022

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults).

Michael Abouyannis, Richard FitzGerald, Mwanajuma Ngama, Hope Mwangudzah, Yvonne K Nyambura, Samson Ngome, Debra Riako, Lawrence Babu, Frida Lewa, Laura Else and 10 more

Open access · goldAbstract read
In one paragraph

Article in Wellcome open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. ImprovingF1000Research · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. [A global core outcome measurement set for snakebite clinical trials].Medecine tropicale et sante internationale · 2023
    Article
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Michael AbouyannisCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID https://orcid.org/0000-0003-4856-4334
Richard FitzGeraldNIHR Royal Liverpool and Broadgreen CRF, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Mwanajuma NgamaKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Hope MwangudzahKEMRI-Wellcome Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-1166-8965
Yvonne K NyamburaKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Samson NgomeKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Debra RiakoKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Lawrence BabuKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Frida LewaKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Laura ElseDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Sujan Dily PenchalaDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Benedict OrindiKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Noni MumbaKEMRI-Wellcome Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-3531-8823
Betty KalamaKEMRI-Wellcome Research Programme, Kilifi, Kenya.
Francis M NdunguKEMRI-Wellcome Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-8977-0030
Ifedayo AdetifaKEMRI-Wellcome Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-2556-9407
Saye KhooNIHR Royal Liverpool and Broadgreen CRF, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
David G LallooCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID https://orcid.org/0000-0001-7680-2200
Nicholas R CasewellCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID https://orcid.org/0000-0002-8035-4719
Mainga HamalubaKEMRI-Wellcome Research Programme, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-0266-1414
Kenya Medical Research Institute · KELiverpool School of Tropical Medicine · GBUniversity of Liverpool · GBRoyal Liverpool and Broadgreen University Hospital NHS Trust · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adaptivechelatorclinical trial.envenomingphase Irepurposesmall moleculeSnakebite

Identifiers

PMID35372700
PMCPMC8961198
OpenAlexW4220764358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.