ArticleBone reports2022
Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture.
Article in Bone reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Innovative biomaterials in promoting intraoral wound healing: Mechanisms, applications, and challenges.Materials today. Bio · 2025Review
- Mesenchymal Stem Cells in Socket Healing and MRONJ.Orthodontics & craniofacial research · 2025Review
- Association between bone turnover markers and alveolar socket healing rate: A cross-sectional study.Oral and maxillofacial surgery · 2025Article
- In vivo dynamics of hard tissue-forming cell origins: Insights from Cre/loxP-based cell lineage tracing studies.The Japanese dental science review · 2024Review
- Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Preventive Effects of Dental Pulp Stem Cell-conditioned Media on Anti-RANKL Antibody-Related Osteonecrosis of the Jaw.Calcified tissue international · 2024Article
- The role of Wnt signaling on Tooth Extraction Wound Healing: Narrative review.The Saudi dental journal · 2024Review
- Comparative analysis of bone healing in subcritical defects with air turbine and electric handpiece in a rat model.PloS one · 2024Article
- Differential effects of clopidogrel and/or aspirin on the healing of tooth extraction wound bone tissue.Frontiers in physiology · 2024Article
- Healing effect of curcumin on tooth extraction sockets in diabetic rats.Journal of applied oral science : revista FOB · 2024Article
- Lepr-Expressing PDLSCs Contribute to Periodontal Homeostasis and Respond to Mechanical Force by Piezo1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Anti-angiogenic drug aggravates the degree of anti-resorptive drug-based medication-related osteonecrosis of the jaw by impairing the proliferation and migration function of gingival fibroblasts.BMC oral health · 2023Article
- Uncovering the unique characteristics of the mandible to improve clinical approaches to mandibular regeneration.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite various reports on the bone healing processes of tooth extraction socket and long bone fracture, the differences of pathological changes during these healing processes remain elusive. This study aims to elucidate the underlying mechanisms behind the pathophysiology of bone regeneration between the tooth extraction socket and femoral fractures through a comparative study. Eight-week-old male mice were used in the experiments. The maxillary first molar was extracted, and intramedullary nailing femoral fracture (semistabilized fracture repair) was performed in the femur. Pathological changes in these bone injuries were investigated by micro-CT, histology, immunohistochemistry, and RT-PCR until day 7 post operation. Pathological changes in drill hole injury created in cortical bone of femur were also examined. Micro-CT analyses revealed increases in mineralized tissues in both the tooth extraction socket and femoral fracture. Histological examinations revealed that tooth socket was repaired by intramembranous ossification, and intramedullary nailing femoral fracture was healed by endochondral ossification. Immunohistochemical investigation revealed that tooth socket healing associated with Sp7-positive cells but not Sox9, aggrecan, and type II collagen, while femoral fracture models exhibited positive signals for all antibodies. RT-PCR analyses revealed the expression of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.