Evidence map›Paper›PMID 35372352›Full record

ArticleFrontiers in cell and developmental biology2022

Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant

Laura Mainz, Mohamed A F E Sarhan, Sabine Roth, Ursula Sauer, Katja Maurus, Elena M Hartmann, Helen-Desiree Seibert, Andreas Rosenwald, Markus E Diefenbacher, Mathias T Rosenfeldt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Laura MainzInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Mohamed A F E SarhanInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Sabine RothInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Ursula SauerComprehensive Cancer Center Mainfranken, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Katja MaurusInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Elena M HartmannInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Helen-Desiree SeibertInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Andreas RosenwaldInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Markus E DiefenbacherBiocenter, Department of Biochemistry and Molecular Biology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Mathias T RosenfeldtInstitute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
University of Würzburg · DEComprehensive Cancer Center Mainfranken · DESalk Institute for Biological Studies · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroautophagy (hereafter referred to as autophagy) is a homeostatic process that preserves cellular integrity. In mice, autophagy regulates pancreatic ductal adenocarcinoma (PDAC) development in a manner dependent on the status of the tumor suppressor gene

Indexed as

ATG7autophagymetastasisp53pancreatic cancer

Identifiers

PMID35372352
PMCPMC8965752
OpenAlexW4220832256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.