ArticleFrontiers in bioengineering and biotechnology2022
Detection of Amyloid-β(1-42) Aggregation With a Nanostructured Electrochemical Sandwich Immunoassay Biosensor.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Self-Assembled EGCG@Zn Fluorescent Nanocomplexes for Sensitive Detection of Amyloid-βJournal of fluorescence · 2026Article
- Portable electrochemical sensing coupled with machine learning for rapid Arabica and Robusta coffee authentication and blend ratio prediction.Food chemistry: X · 2026Article
- Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.Biosensors · 2026Review
- Nanoparticle-Based Tools to Study Hallmarks of Aging at the Molecular Level.International journal of nanomedicine · 2026Review
- Application of Nanoparticles in the Diagnosis and Treatment of Colorectal Cancer.Anti-cancer agents in medicinal chemistry · 2024Review
- SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer's Disease.Biosensors · 2023Review
- Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer's Disease.Biosensors · 2023Review
- SiC Electrochemical Sensor Validation for Alzheimer AβMicromachines · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid-β(1-42) [Aβ(1-42)] oligomer accumulations are associated with physiologic alterations in the brains of individuals with Alzheimer's disease. In this study, we demonstrate that a nanostructured gold electrode with deposited gold nanoparticles, induced via electrochemical impedance spectroscopy (EIS), may be used as an Aβ(1-42) conformation biosensor for the detection of Alzheimer's disease. Monoclonal antibodies (12F4) were immobilized on self-assembled monolayers of the electrochemical sandwich immunoassay biosensor to capture Aβ(1-42) monomers and oligomers. Western blot and fluorescence microscopy analyses were performed to confirm the presence of Aβ(1-42) monomers and oligomers. EIS analysis with an equivalent circuit model was used to determine the concentrations of different Aβ(1-42) conformations in this study. We identified conformations of Aβ(1-42) monomers and Aβ(1-42) oligomers using probe antibodies (12F4) by employing EIS.
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Registered trials
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