Evidence map›Paper›PMID 35372195›Full record

ArticleFrontiers in public health2022

A Data-Driven Framework for Identifying Intensive Care Unit Admissions Colonized With Multidrug-Resistant Organisms.

Çaǧlar Çaǧlayan, Sean L Barnes, Lisa L Pineles, Anthony D Harris, Eili Y Klein

Abstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Host-Bacterium Interaction Mechanisms inInternational journal of molecular sciences · 2023
    Pooled it
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  8. Metabolites · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Çaǧlar ÇaǧlayanAsymmetric Operations Sector, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Sean L BarnesDepartment of Decision, Operations and Information Technologies (DO&IT), R.H. Smith School of Business, University of Maryland, College Park, MD, United States.
Lisa L PinelesDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Anthony D HarrisDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Eili Y KleinDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Funding

NCEZID CDC HHS U01 CK000536NCEZID CDC HHS U01 CK000589
6 · The paper itself

Abstract

Background: The rising prevalence of multi-drug resistant organisms (MDROs), such as Methicillin-resistant Materials and Methods: Leveraging data from electronic healthcare records and a unique MDRO universal screening program, we developed a data-driven modeling framework to predict MRSA, VRE, and CRE colonization upon intensive care unit (ICU) admission, and identified the associated socio-demographic and clinical factors using logistic regression (LR), random forest (RF), and XGBoost algorithms. We performed threshold optimization for converting predicted probabilities into binary predictions and identified the cut-off maximizing the sum of sensitivity and specificity. Results: Four thousand six hundred seventy ICU admissions (3,958 patients) were examined. MDRO colonization rate was 17.59% (13.03% VRE, 1.45% CRE, and 7.47% MRSA). Our study achieved the following sensitivity and specificity values with the best performing models, respectively: 80% and 66% for VRE with LR, 73% and 77% for CRE with XGBoost, 76% and 59% for MRSA with RF, and 82% and 83% for MDRO (i.e., VRE or CRE or MRSA) with RF. Further, we identified several predictors of MDRO colonization, including long-term care facility stay, current diagnosis of skin/subcutaneous tissue or infectious/parasitic disease, and recent isolation precaution procedures before ICU admission. Conclusion: Our data-driven modeling framework can be used as a clinical decision support tool for timely predictions, characterization and identification of high-risk patients, and selective and timely use of infection control measures in ICUs.

Indexed as

Drug Resistance, Multiple, BacterialIntensive Care UnitsMethicillin-Resistant Staphylococcus aureusVancomycin-Resistant EnterococciElectronic Health RecordsHumansModels, TheoreticalPatient Admissioncarbapenem-resistant Enterobacteriaceae (CRE)data-centric analyticshealthcare-associated infections (HAIs)machine learning (ML)Methicillin-resistant Staphylococcus aureus (MRSA)multidrug-resistant organisms (MDROs)predictive analyticsvancomycin-resistant enterococci (VRE)

Identifiers

PMID35372195
PMCPMC8968755

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.