Evidence map›Paper›PMID 35372176›Full record

ArticleFrontiers in pediatrics2022

A Timely Administration of Antenatal Steroids Is Highly Protective Against Intraventricular Hemorrhage: An Observational Multicenter Cohort Study of Very Low Birth Weight Infants.

Ingmar Fortmann, Luisa Mertens, Hannah Boeckel, Berthold Grüttner, Alexander Humberg, Mariana Astiz, Claudia Roll, Isabell Rickleffs, Achim Rody, Christoph Härtel and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  7. Review
  8. Reduced racial disparities among newborns with intraventricular hemorrhage.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  9. Administration of Antenatal Corticosteroids: Optimal Timing.Geburtshilfe und Frauenheilkunde · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ingmar FortmannDepartment of Pediatrics, University of Lüebeck, Lübeck, Germany.
Luisa MertensDepartment of Obstetrics and Gynecology, University of Lübeck, Lübeck, Germany.
Hannah BoeckelDepartment of Pediatrics, University of Lüebeck, Lübeck, Germany.
Berthold GrüttnerDepartment of Obstetrics and Gynecology, University of Cologne, Cologne, Germany.
Alexander HumbergDepartment of Pediatrics, University of Lüebeck, Lübeck, Germany.
Mariana AstizCenter of Brain, Behavior and Metabolism, Institute of Neurobiology, University of Lübeck, Lübeck, Germany.
Claudia RollDepartment of Pediatrics, Vestisch Children's Hospital Datteln, University Witten/Herdecke, Datteln, Germany.
Isabell RickleffsDepartment of Pediatrics, University of Lüebeck, Lübeck, Germany.
Achim RodyDepartment of Obstetrics and Gynecology, University of Lübeck, Lübeck, Germany.
Christoph HärtelDepartment of Pediatrics, University Hospital of Würzburg, Würzburg, Germany.
Egbert HertingDepartment of Pediatrics, University of Lüebeck, Lübeck, Germany.
Wolfgang GöpelDepartment of Pediatrics, University of Lüebeck, Lübeck, Germany.
Verena BossungDepartment of Obstetrics and Gynecology, University of Lübeck, Lübeck, Germany.
University of Lübeck · DEGerman Center for Infection Research · DEUniversitätsklinikum Würzburg · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The aim of the study is to evaluate the influence of the timing of antenatal steroids (ANSs) on neonatal outcome of very low birth weight infants (VLBWI) born before 30 weeks of gestation in the German Neonatal Network. Methods: The German Neonatal Network is a large population-based cohort study enrolling VLBWIs since 2009. We included 672 neonates, who were born between January 1, 2009 and December 31, 2019 in our analysis in 10 selected centers. Infants were divided into four subgroups based on the interval between the first steroid administration and preterm birth: (I) two doses of betamethasone, ANS-birth interval: >24 h to 7 days, Results: An ANS-birth interval of 24 h to 7 days after the first dose was associated with a reduced risk for intraventricular hemorrhage (OR 0.17; 95% CI 0.09-0.31, Conclusion: Our observational data indicate that an ANS-birth interval of 24 h to 7 days is strongly associated with a reduced risk of intraventricular hemorrhage in VLBWIs. Further research is needed to improve the prediction of preterm birth in order to achieve a timely administration of antenatal steroids that may improve neonatal outcomes such as intraventricular hemorrhage.

Indexed as

antenatal steroidsintraventricular hemorrhageneonatal outcomepreterm birthVLBWI

Identifiers

PMID35372176
PMCPMC8965892
OpenAlexW4220888805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.