ArticleFrontiers in cellular and infection microbiology2022
Toll-Like Receptor 2 Modulates Pulmonary Inflammation and TNF-α Release Mediated by
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Neutrophil-to-lymphocyte ratio for predicting disease severity and outcomes in children with Mycoplasma pneumoniae pneumonia: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Global research trends on the associations between the microbiota and lung cancer: a visualization bibliometric analysis (2008-2023).Frontiers in microbiology · 2024Pooled it
- The cell with many faces: lung macrophage plasticity and function in response to environmental and pathogenic insults.Physiological reviews · 2026Review
- Characteristics and influencing factors of bronchoalveolar lavage fluid cellular patterns in children withTranslational pediatrics · 2026Article
- Attenuated efficacy of Streptococcus salivarius K12 against Mycoplasma pneumoniae infection in mice.BMC microbiology · 2026Article
- Levels of Toll-Like Receptor 2, Myeloid Differentiation Primary Response 88 and Mucin 5AC, Oligomeric Mucus/Gel-Forming in Bronchoalveolar Lavage Fluid for Predicting SevereInfection and drug resistance · 2026Article
- Identification of clinical phenotypes and prediction model for the mixed-infection phenotype of pediatric community-acquired pneumonia based on unsupervised machine learning.Frontiers in pediatrics · 2026Article
- Comparative progress on the mechanisms of airway mucosal injury induced by different pathogens: SARS-CoV-2, influenza A virus, and Mycoplasma pneumoniae.Frontiers in cellular and infection microbiology · 2026Review
- Research progress on the mechanisms of mucus retention after mycoplasma pneumoniae infection.Frontiers in cellular and infection microbiology · 2026Review
- Comparing differences in onset and clinical manifestations between children and adults withFrontiers in public health · 2026Article
- Clinical characteristics and cytokine profiles for early prediction of severeFrontiers in pediatrics · 2026Article
- Correlation between 25-hydroxyvitamin D, N-terminal pro-brain natriuretic peptide, inflammatory factors and myocardial injury in children with mycoplasma pneumoniae pneumonia.BMC pediatrics · 2025Article
- Panoramic quantitative and visualization-based bibliometric analysis of Mycoplasma pneumoniae.Infection · 2025Article
- Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation.Journal of translational medicine · 2025Article
- Peptide Antigen Modifications Influence the On-Target and Off-Target Antibody Response for an Influenza Subunit Vaccine.Vaccines · 2025Article
- Interplay between Pro-inflammatory Mediators and Oxidative Stressinvolved Recurrent Chronic Heart Failure in Elderly Patients with Coronary Stents.Current medicinal chemistry · 2025Article
- Predictive Value of Traditional and Novel Composite Inflammatory Indicators for Severe and Refractory Mycoplasma pneumoniae Pneumonia in Children.Journal of inflammation research · 2025Article
- Age-Specific Cytokine Profiling in Children withJournal of inflammation research · 2025Article
- [Protective effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
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Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To investigate the roles that Toll-like receptors (TLRs) play in lung inflammation mediated by Methods: The changes in TLRs and tumor necrosis factor alpha (TNF-α) in peripheral blood of children with Results: TNF-α levels in peripheral blood of children with MPP were higher than those in non-infected children, and children with refractory MPP had the highest levels of TNF-α and TLR2. TNF-α secretion and TLR2, myeloid differentiation primary response 88 (MyD88) and phospho-p65(p-p65) levels were increased in stimulated cells. TNF-α secretion was suppressed upon siRNA-mediated TLR2 silencing. Pharmacological inhibition of nuclear factor-kappa B (NF-κB) and MyD88 effectively reduced TNF-α expression. Compared with wild-type mice, the TNF-α in serum and BALF decreased, and lung pro-inflammatory response was partially suppressed in TLR2-/- mice. Conclusion: We concluded that TLR2 regulates
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.