Evidence map›Paper›PMID 35372077›Full record

ReviewFrontiers in oncology2022

Immunotherapy in Breast Cancer and the Potential Role of Liquid Biopsy.

Mark Jesus M Magbanua, Ozge Gumusay, Razelle Kurzrock, Laura J van 't Veer, Hope S Rugo

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
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  5. Article
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  8. Peripheral TNF-α and CD8Breast cancer (Dove Medical Press) · 2025
    Article
  9. Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mark Jesus M MagbanuaDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States.
Ozge GumusayHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, United States.
Razelle KurzrockWorldwide Innovative Network (WIN) for Personalized Cancer Therapy Consortium, Villejuif, France.
Laura J van 't VeerDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States.
Hope S RugoDivision of Hematology Oncology, University of California San Francisco, San Francisco, CA, United States.
University of California, San Francisco · US

Funding

Strategy for combining circulating tumor DNA (ctDNA) and magnetic resonance imaging (MRI) measures of tumor burden for prediction of response and outcome in neoadjuvant-treated early breast cancerR01CA255442 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, WEN, MAGBANUA, MARK JESUS · 2021 to 2025
$3.3M
NCI NIH HHS R01 CA255442
6 · The paper itself

Abstract

Liquid biopsy biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), are noninvasive diagnostics that could complement predictive and prognostic tools currently used in the clinic. Recent trials of immunotherapy have shown promise in improving outcomes in a subset of breast cancer patients. Biomarkers could improve the efficacy of immune checkpoint inhibitors by identifying patients whose cancers are more likely to respond to immunotherapy. In this review, we discuss the current applications of liquid biopsy and emerging technologies for evaluation of immunotherapy response and outcomes in breast cancer. We also provide an overview of the status of immunotherapy in breast cancer.

Indexed as

biomarkersbreast cancercirculating tumor cellscirculating tumor DNAimmunotherapyliquid biopsy

Identifiers

PMID35372077
PMCPMC8964955
OpenAlexW4220760684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.