ArticleQuantitative imaging in medicine and surgery2022
Clinical feasibility of using effective atomic number maps derived from non-contrast spectral computed tomography to identify non-calcified atherosclerotic plaques: a preliminary study.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 8 citations in OpenAlex.
- Development of an explainable machine learning model for 3-year cardiovascular risk prediction in new-onset type 2 diabetes using the TyG index and ultrasound features.BMC medical informatics and decision making · 2025Article
- Applicability of Effective Atomic Number (Zeff) Image Analysis of Coronary Plaques Measured With Photon- Counting Computed Tomography.Investigative radiology · 2025Article
- Efficacy of dual-layer spectral detector computed tomography for detecting early ischemic changes in patients with acute ischemic stroke: A pilot study.Journal of clinical imaging science · 2025Article
- Improving cardiovascular risk prediction with machine learning: a focus on perivascular adipose tissue characteristics.Biomedical engineering online · 2024Article
- Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers.Nanotheranostics · 2023Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
Background: To assess the clinical feasibility of using effective atomic number (Zeff) maps derived from non-contrast-enhanced computed tomography (NCECT) scans obtained by dual-layer spectral computed tomography (DLCT) to identify non-calcified atherosclerotic plaques. Methods: A total of 37 patients with 86 non-calcified atherosclerotic plaques confirmed by contrast-enhanced CT (CECT) were enrolled in this retrospective study. Both spectral-based-images (SBI) and conventional images (CI) were reconstructed from NCECT and CECT scans. The presence of plaques on NCECT Zeff maps and CIs were independently assessed by 2 radiologists. In CECT scans, plaques and regions of interest (ROIs) in vessel lumens were assessed with CT attenuation and Zeff values, and the proportion of plaques was determined as Area (plaque)/Area (vessel). The CT and Zeff values for plaques and blood were recorded from both CECT and NCECT scans. Contrast-to-noise ratios (CNRs) of the plaques were calculated and compared using CT attenuation and Zeff values. Finally, interobserver agreement was evaluated. Results: A total of 47 of the 86 (54.7%) plaques were identified on Zeff map images derived from the NCECT scans while only 7 (8.1%) plaques were identified on the CI. There was no significant difference between the mean vessel ROI area measured on CIs and that measured on Zeff map images (502.19 Conclusions: Zeff map images derived from NCECT SBI with DLCT provide a potentially feasible approach for identifying non-calcified atherosclerotic plaques, which might be clinically useful for the screening of asymptomatic at-risk patients.
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