Evidence map›Paper›PMID 35371083›Full record

ArticleFrontiers in immunology2022

The Diversity of Serum Anti-DSG3 IgG Subclasses Has a Major Impact on Pemphigus Activity and Is Predictive of Relapses After Treatment With Rituximab.

Marie-Laure Golinski, Alexandre Lemieux, Maud Maho-Vaillant, Marion Barray, Laurent Drouot, Damien Schapman, Marie Petit, Michael Hertl, Olivier Boyer, Sébastien Calbo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Marie-Laure GolinskiNormandie Univ, UNIROUEN, Inserm U1234, CHU Rouen, Department of Dermatology, Rouen, France.
Alexandre LemieuxNormandie Univ, UNIROUEN, Inserm U1234, CHU Rouen, Department of Dermatology, Rouen, France.
Maud Maho-VaillantNormandie Univ, UNIROUEN, Inserm U1234, CHU Rouen, Department of Dermatology, Rouen, France.
Marion BarrayNormandie Univ, UNIROUEN, Inserm U1234, Rouen, France.
Laurent DrouotNormandie Univ, UNIROUEN, Inserm U1234, Rouen, France.
Damien SchapmanNormandie Univ, UNIROUEN, PRIMACEN, Rouen, France.
Marie PetitNormandie Univ, UNIROUEN, Inserm U1234, Rouen, France.
Michael HertlDepartment of Dermatology and Allergology, Philipps University, Marburg, Germany.
Olivier BoyerNormandie Univ, UNIROUEN, Inserm U1234, CHU Rouen, Department of Immunology, Rouen, France.
Sébastien CalboNormandie Univ, UNIROUEN, Inserm U1234, Rouen, France.
Pascal JolyNormandie Univ, UNIROUEN, Inserm U1234, CHU Rouen, Department of Dermatology, Rouen, France.
Vivien HébertNormandie Univ, UNIROUEN, Inserm U1234, CHU Rouen, Department of Dermatology, Rouen, France.
Inserm · FRNormandie Université · FRPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We studied the distribution and Methods: We longitudinally studied the distribution of anti-DSG3 IgG subclasses (before Results: Sixty-five sera were assessed at baseline (33 from patients treated with rituximab and 32 with corticosteroids). Sixty-three percent of these baseline sera contained 2 or more anti-DSG3 IgG subclasses Conclusion: The serum levels and number of anti-DSG3 IgG subclasses drive the pathogenic effect of pemphigus sera and may predict the occurrence of relapses.

Indexed as

PemphigusAutoantibodiesDesmoglein 3HumansImmunoglobulin GRecurrenceRituximabAutoantibodiesDesmoglein 3Immunoglobulin GRituximabdesmoglein 3immunoglobulin subclassespathogenicitypemphigusrituximab

Identifiers

PMID35371083
PMCPMC8965561
OpenAlexW4220905962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.