Evidence map›Paper›PMID 35371073›Full record

ArticleFrontiers in immunology2022

Host Immunity Influences the Composition of Murine Gut Microbiota.

Vincent Van Averbeke, Matilda Berkell, Mohamed Mysara, Juan Pablo Rodriguez-Ruiz, Basil Britto Xavier, Fien H R De Winter, Bart 's Jongers, Ravi Kumar Jairam, An Hotterbeekx, Herman Goossens and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Collagen Peptides andFood science & nutrition · 2025
    Article
  5. Article
  6. Biology · 2023
    Article
  7. Intrahost evolution of the gut microbiota.Nature reviews. Microbiology · 2023
    Review
  8. BothNutrients · 2023
    Article
  9. Article
  10. Review
  11. Microbiota signatures associated with invasiveFrontiers in cellular and infection microbiology · 2023
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Vincent Van AverbekeMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Matilda BerkellMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Mohamed MysaraMicrobiology Unit, Belgian Nuclear Research Centre (SCK-CEN), Mol, Belgium.
Juan Pablo Rodriguez-RuizLaboratory of Medical Microbiology - Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Basil Britto XavierLaboratory of Medical Microbiology - Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Fien H R De WinterMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Bart 's JongersMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Ravi Kumar JairamMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
An HotterbeekxMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Herman GoossensLaboratory of Medical Microbiology - Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
E Suzanne CohenBioscience Asthma, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Surbhi Malhotra-KumarLaboratory of Medical Microbiology - Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Samir Kumar-SinghMolecular Pathology Group, Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
University of Antwerp · BEAstraZeneca (United Kingdom) · GBBelgian Nuclear Research Centre · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of gut microbiota on host immunity is widely studied, and its disturbance has been linked to several immune-mediated disorders. Conversely, whether and how inherently disturbed canonical Th1 (pro-inflammatory) and/or Th2 (anti-inflammatory) immune pathways modify the host microbiome is not sufficiently investigated. Here, we characterized the humoral, cellular, and cytokine immunity, and associated alterations in gut microbiota of naïve wild-type mice (C57BL/6 and BALB/c), and mice with deficiencies in Th2 responses (IL-4Rα and IL-33 knockout mice) or in both Th1 and Th2 responses (NOD

Indexed as

Gastrointestinal MicrobiomeAnimalsCytokinesInterleukin-33MiceMice, Inbred BALB CMice, Inbred C57BLRNA, Ribosomal, 16SCytokinesInterleukin-33RNA, Ribosomal, 16SBALB/cC57BL/6cytokines/chemokinesIL-33 knockoutIL-4Rα knockoutNSGT-cell analysisTh1-Th2 balance

Identifiers

PMID35371073
PMCPMC8965567
OpenAlexW4220819912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.