ArticleFrontiers in immunology2022
Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Heliox versus trimix in closed-circuit rebreather diving: A comparative study of pulmonary and decompression stress in male divers.Physiological reports · 2026Article
- Circulating Bubbles in Decompression Sickness: Pathophysiology and Experimental Models.Biomolecules · 2026Review
- Characteristic MR Imaging Findings of Cerebral Air Embolism Infarcts: A Case Series.AJNR. American journal of neuroradiology · 2024Article
- Spontaneous Air Embolism Following Contrast Injection: A Diagnostic Challenge in a Post-COVID-19 Patient.Cureus · 2024Article
- Femoral nailing associated with bone marrow emboli in pigs induced a specific increase in blood IL-6 and broad inflammatory responses in the heart and lungs.Frontiers in immunology · 2024Article
- Cerebral air embolism: neurologic manifestations, prognosis, and outcome.Frontiers in neurology · 2024Article
- Comparison of two viscoelastic testing devices in a porcine model of surgery, hemorrhage and resuscitation.Frontiers in bioengineering and biotechnology · 2024Article
- Plasma Proteomics-Based Discovery of Mechanistic Biomarkers of Hyperbaric Stress and Pulmonary Oxygen Toxicity.Metabolites · 2023Article
- Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies.Frontiers in immunology · 2023Review
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Air embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation Methods: Forty-five landrace pigs, average 17 kg (range 8.5-30), underwent intravenous air infusion for 300 or 360 minutes (n=29) or served as sham (n=14). Fourteen pigs were excluded due to e.g. infections or persistent foramen ovale. Blood was analyzed for white blood cells (WBC), complement activation (C3a and terminal C5b-9 complement complex [TCC]), cytokines, and hemostatic parameters including thrombin-antithrombin (TAT) using immunoassays and rotational thromboelastometry (ROTEM). Lung tissue was analyzed for complement and cytokines using qPCR and immunoassays. Results are presented as medians with interquartile range. Results: In 24 pigs receiving air infusion, WBC increased from 17×10 Conclusion: Venous air embolism in pigs activated C3 without a corresponding C5 activation and triggered thromboinflammation, consistent with a C3-dependent mechanism. C3-inhibition might represent a therapeutic approach to attenuate this response.
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