Evidence map›Paper›PMID 35371023›Full record

ArticleFrontiers in immunology2022

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.

Ken-Ichi Hirano, Hiroyuki Hosokawa, Takashi Yahata, Kiyoshi Ando, Masayuki Tanaka, Jin Imai, Masaki Yazawa, Masato Ohtsuka, Naoko Negishi, Sonoko Habu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ken-Ichi HiranoDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.
Hiroyuki HosokawaDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.
Takashi YahataInstitute of Medical Sciences, Tokai University, Isehara, Japan.
Kiyoshi AndoInstitute of Medical Sciences, Tokai University, Isehara, Japan.
Masayuki TanakaSupport Center of Medical Research and Education, Tokai University School of Medicine, Isehara, Japan.
Jin ImaiDivison of Gastroenterology and Hepatology, Tokai University School of Medicine, Isehara, Japan.
Masaki YazawaDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.
Masato OhtsukaInstitute of Medical Sciences, Tokai University, Isehara, Japan.
Naoko NegishiDepartment of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Sonoko HabuDepartment of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Takehito SatoDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.
Katsuto HozumiDepartment of Immunology, Tokai University School of Medicine, Isehara, Japan.
Tokai University · JPJuntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-cell development in the thymus is dependent on Notch signaling induced by the interaction of Notch1, present on immigrant cells, with a Notch ligand, delta-like (Dll) 4, on the thymic epithelial cells. Phylogenetic analysis characterizing the properties of the Dll4 molecule suggests that Dll4 emerged from the common ancestor of lobe- and ray-finned fishes and diverged into bony fishes and terrestrial organisms, including mammals. The thymus evolved in cartilaginous fishes before Dll4, suggesting that T-cell development in cartilaginous fishes is dependent on Dll1 instead of Dll4. In this study, we compared the function of both Dll molecules in the thymic epithelium using

Indexed as

Calcium-Binding ProteinsIntracellular Signaling Peptides and ProteinsAdaptor Proteins, Signal TransducingAnimalsEpitheliumLigandsMammalsMembrane ProteinsMicePhylogenyAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDlk1 protein, mouseIntracellular Signaling Peptides and ProteinsLigandsMembrane Proteinsdelta-like 1delta-like 4Notch1Notch2phylogenesisthymus

Identifiers

PMID35371023
PMCPMC8968733
OpenAlexW4220979050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.