ArticleFrontiers in endocrinology2022
TG: HDL-C Ratio as Insulin Resistance Marker for Metabolic Syndrome in Children With Obesity.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- The cutoff value of serum triglyceride/high-density lipoprotein cholesterol ratio of high pericardial adipose tissue in Korean: a retrospective study.Korean journal of family medicine · 2026Article
- Ratio That Reveals Risk: Defining TG:HDL-C Ratio Cutoff for Insulin Resistance in Adolescents with Obesity.Children (Basel, Switzerland) · 2026Article
- The role of visceral obesity surrogate markers in predicting cardiovascular disease: Insights from the CHARLS study.Medicine · 2026Article
- Cluster analysis with body composition data for health risk assessment in children.Pediatric research · 2026Article
- Fermented Black Soybean and Dehulled Adlay Improve Metabolic Syndrome via AMPK-SIRT1 Activation and Gut Microbiota Modulation.Journal of agricultural and food chemistry · 2026Article
- Early detection and risk stratification of insulin resistance in children and adolescents with excess weight: a sdLDL/oxLDL-Based model.Clinical and experimental medicine · 2026Article
- Article
- The triglyceride HDL cholesterol ratio predicts sarcopenia risk in an aging National cohort from China.Scientific reports · 2026Article
- Association and discriminative value of insulin resistance surrogate markers for aortic stiffness in asymptomatic adults.Frontiers in cardiovascular medicine · 2026Article
- Association between triglyceride-to-high-density lipoprotein cholesterol ratio and albuminuria in patients with type 2 diabetes: a cross-sectional study.Frontiers in nutrition · 2026Article
- Evaluation of novel inflammatory biomarkers in overweight, obese, and morbidly obese children: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Assessing Metabolic Syndrome Risk in Children and Adolescents with Prader-Willi Syndrome: A Comparison of Index Performance.Journal of clinical medicine · 2025Article
- Correlations Between Coronary Artery Calcium Scores and Vitamin A, the Triglyceride/High-Density Lipoprotein Ratio, and Glycated Hemoglobin in At-Risk Individuals in Saudi Arabia: A Comprehensive Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Health Information Technology Usability Evaluation Scale in China: Instrument Validation Study.Journal of medical Internet research · 2025Article
- Intelligent predictive risk assessment and management of sarcopenia in chronic disease patients using machine learning and a web-based tool.European journal of medical research · 2025Article
- Triglyceride-glucose index and triglyceride-to-high-density lipoprotein cholesterol ratio in predicting severity of acute pancreatitis: a cross-sectional clinical study.BMC gastroenterology · 2025Article
- Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management.Cureus · 2025Review
- Correlation between logFrontiers in endocrinology · 2025Article
- Body composition shapes cardiometabolic risk in children with multifactorial dyslipidemia.Frontiers in nutrition · 2025Article
- Uric acid and unhealthy metabolic phenotype in Colombian children.Pediatric endocrinology, diabetes, and metabolism · 2025Article
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8 authors.
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Abstract
Insulin resistance (IR) is an important variable in the diagnosis of metabolic syndrome (MetS). Currently, IR is not part of the existing pediatric definition of MetS, instead elevated fasting blood glucose (FBG) is measured as an indicator of hyperglycemia. Arguably, many obese children with severe IR are still able to regulate their FBG well. Hence, this study aimed to assess the utility of triglyceride-to-high-density lipoprotein cholesterol (TG : HDL-C) ratio as an IR marker in the modeling of pediatric MetS among children with obesity using structural equation modeling (SEM). A total of 524 blood samples from children with obesity (age 10-16 years old) were analyzed for FBG, lipids, insulin, leptin, and adiponectin. Both exploratory (EFA) and confirmatory factor analysis (CFA) were used to examine TG : HDL-C ratio as an IR marker in pediatric MetS. EFA shows that TG: HDL-C ratio (standardized factor loading = 0.904) groups together with homeostasis model assessment-estimated insulin resistance (HOMA-IR) (standardized factor loading = 0.664), indicating a strong correlation to the IR factor. Replacing FBG with TG: HDL-C ratio improved the modeling of MetS structure in children with obesity. Our MetS model of TG: HDL-C ratio as IR component shows comparable model fitness indices (goodness of fit, Akaike's information criterion, and Bayesian information criterion) with leptin:adiponectin ratio (platinum standard for adiposity:IR marker) model. The least model fit was seen when using FBG as an IR surrogate. TG : HDL-C ratio performed better as IR surrogate in MetS structures (standardized factor loading = 0.39) compared to FBG (standardized factor loading = 0.27). TG: HDL-C ratio may be considered as an IR component in pediatric MetS.
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