Evidence map›Paper›PMID 35370943›Full record

ArticleFrontiers in endocrinology2022

Peroxiredoxin 6 Modulates Insulin Secretion and Beta Cell Death

Francesca Pacifici, David Della-Morte, Barbara Capuani, Andrea Coppola, Maria Giovanna Scioli, Giulia Donadel, Aikaterini Andreadi, Fabiola Ciccosanti, Gian Maria Fimia, Alfonso Bellia and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Pitfalls of Mitochondrial Redox Signaling Research.Antioxidants (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Experimental Approaches to Diabetes Mellitus.The Eurasian journal of medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Francesca PacificiDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
David Della-MorteDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Barbara CapuaniDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Andrea CoppolaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Maria Giovanna ScioliAnatomic Pathology, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Giulia DonadelDepartment of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
Aikaterini AndreadiDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Fabiola CiccosantiDepartment of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases L. Spallanzani, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Gian Maria FimiaDepartment of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases L. Spallanzani, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Alfonso BelliaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Augusto OrlandiAnatomic Pathology, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Davide LauroDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
University of Rome Tor Vergata · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In pancreatic beta cells, mitochondrial metabolism controls glucose-stimulated insulin secretion (GSIS) by ATP production, redox signaling, and calcium (Ca

Indexed as

Insulin-Secreting CellsPeroxiredoxin VIAnimalsApoptosisInsulinInsulin SecretionMiceMitochondrial DynamicsInsulinPeroxiredoxin VIPrdx6 protein, mouseapoptosisdiabetes mellitusinsulin secretionmitochondrial functionmitochondrial morphologyoxidative stress

Identifiers

PMID35370943
PMCPMC8971298
OpenAlexW4220917974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.