Transcriptome Analysis Reveal Candidate Genes and Pathways Responses to Lactate Dehydrogenase Inhibition (Oxamate) in Hyperglycemic Human Renal Proximal Epithelial Tubular Cells.

Zhimin Wang, Dan Hao, Dong Fang, Jiating Yu, Xiao Wang, Guijun Qin

Abstract read

In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

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1 citing paper in PubMed.

Epigenetic modification in diabetic kidney disease.Frontiers in endocrinology · 2023
Review

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Authors and funding

6 authors.

Zhimin WangDivision of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Dan HaoShaanxi Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Northwest A&F University, Yangling, China.

Dong FangDepartment of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing, China.

Jiating YuDivision of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Xiao WangKonge Larsen ApS, Kongens Lyngby, Denmark.

Guijun QinDivision of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is the leading cause of both chronic kidney disease (CKD) and end-stage renal disease (ESRD). Previous studies showed that oxamate could regulate glycemic homeostasis and impacted mitochondria respiration in a hyperglycemia-dependent manner in the rat proximal tubular cells. To explore the transcriptome gene expression profiling of kidney tissues in human renal proximal epithelial tubular cell line (HK-2), we treated HK-2 cells with high D-glucose (HG) for 7 days before the addition of 40 mM oxamate for a further 24 hours in the presence of HG in this study. Afterwards, we identified 3,884 differentially expressed (DE) genes based on adjusted

Indexed as

Diabetic NephropathiesL-Lactate DehydrogenaseAnimalsGene Expression ProfilingGene Regulatory NetworksHumansRatsTranscriptomeL-Lactate Dehydrogenasebiological enrichmentdiabetic kidney diseasehigh D-glucoseHK-2 cellsoxamatetranscriptomicsWGCNA

Identifiers

PMID35370938

DOI10.3389/fendo.2022.785605

PMCPMC8970056

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