Evidence map›Paper›PMID 35370901›Full record

ArticleFrontiers in neurology2022

Tuberculous Meningitis in Children: A Forgotten Public Health Emergency.

Karen du Preez, Helen E Jenkins, Peter R Donald, Regan S Solomons, Stephen M Graham, H Simon Schaaf, Jeffrey R Starke, Anneke C Hesseling, James A Seddon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Karen du PreezDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Helen E JenkinsDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, United States.
Peter R DonaldDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Regan S SolomonsDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stephen M GrahamDepartment of Paediatrics and Murdoch Children's Research Institute, Centre for International Child Health, University of Melbourne Royal Children's Hospital, Melbourne, VIC, Australia.
H Simon SchaafDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Jeffrey R StarkeDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Anneke C HesselingDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
James A SeddonDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stellenbosch University · ZADesmond Tutu HIV Foundation · ZABaylor College of Medicine · USBoston University · USImperial College London · GBMurdoch Children's Research Institute · AU

Funding

Evaluating the tuberculosis epidemic in South Africa using a novel ten-year cohortR01AI152126 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI JENKINS, HELEN E., SCOTT, LESLEY · 2020 to 2024
$1.6M
Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis.K43TW011006 · FIC · STELLENBOSCH UNIVERSITY · PI DU PREEZ, KAREN · 2020 to 2024
$622k
Tracking tuberculosis patients in Ukraine to understand pathways through care and the impact of geographic movementsR03AI164123 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JENKINS, HELEN E. · 2021 to 2022
$165k
FIC NIH HHS K43 TW011006Medical Research Council MR/R007942/1NIAID NIH HHS R03 AI164123
6 · The paper itself

Abstract

Tuberculous meningitis (TBM) remains a major cause of morbidity and mortality in children with tuberculosis (TB), yet there are currently no estimates of the global burden of pediatric TBM. Due to frequent non-specific clinical presentation and limited and inadequate diagnostic tests, children with TBM are often diagnosed late or die undiagnosed. Even when diagnosed and treated, 20% of children with TBM die. Of survivors, the majority have substantial neurological disability with significant negative impact on children and their families. Surveillance data on this devastating form of TB can help to quantify the contribution of TBM to the overall burden, morbidity and mortality of TB in children and the epidemiology of TB more broadly. Pediatric TBM usually occurs shortly after primary infection with

Indexed as

childrenpediatricsurveillancetuberculosistuberculous meningitis

Identifiers

PMID35370901
PMCPMC8970690
OpenAlexW4221104136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.