Evidence map›Paper›PMID 35370900›Full record

ArticleFrontiers in neurology2022

Case Report: The Imperfect Association Between Craniofacial Lesion Burden and Pain in Fibrous Dysplasia.

Emma Golden, Fan Zhang, Daryl J Selen, David Ebb, Laura Romo, Laura A Drubach, Nehal Shah, Lauren J O'Donnell, Jordan D Lemme, Rachel Myers and 6 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Bone pain in fibrous dysplasia does not rely on aberrant sensory nerve sprouting or neuroma formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  7. Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome.The Journal of clinical endocrinology and metabolism · 2024
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Emma GoldenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Fan ZhangDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Daryl J SelenEndocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States.
David EbbDepartment of Pediatric Hematology Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Laura RomoHead and Neck Imaging, Department of Radiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.
Laura A DrubachDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Nehal ShahDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Lauren J O'DonnellDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Jordan D LemmeDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Rachel MyersDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Mariesa CayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Henry M KronenbergEndocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States.
Carl-Fredrik WestinDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Alison M BoyceMetabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States.
Leonard B KabanDepartment of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA, United States.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USMassachusetts General Hospital · USNational Institutes of Health · US

Funding

Metabolic Bone Disorders UnitZIADE000758 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI BOYCE, ALISON · 2021 to 2025
$8.9M
6 · The paper itself

Abstract

Patients with fibrous dysplasia (FD) often present with craniofacial lesions that affect the trigeminal nerve system. Debilitating pain, headache, and migraine are frequently experienced by FD patients with poor prognosis, while some individuals with similar bone lesions are asymptomatic. The clinical and biological factors that contribute to the etiopathogenesis of pain in craniofacial FD are largely unknown. We present two adult females with comparable craniofacial FD lesion size and location, as measured by

Indexed as

craniofacial lesionsfibrous dysplasiaheadachemigrainepaintrigeminal nerve system

Identifiers

PMID35370900
PMCPMC8966612
OpenAlexW4220927255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.