ArticleFrontiers in neurology2022
Alterations of the White Matter in Patients With Knee Osteoarthritis: A Diffusion Tensor Imaging Study With Tract-Based Spatial Statistics.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis.Scientific reports · 2023Pooled it
- Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients.CNS neuroscience & therapeutics · 2023Trial
- Altered activation patterns of sensorimotor cortex during level walking and stair climbing in patients with knee osteoarthritis: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Evaluating the Effect of Electroacupuncture in Knee Osteoarthritis: Protocol for a Multicenter Randomized Controlled Trial.Journal of pain research · 2026Article
- Multimodal neuroimaging insights into central mechanisms of overactive bladder with an empty bladder: a cross-sectional study.European journal of medical research · 2025Article
- Review
- Differences in sensory-motor cortex activation patterns during level and stair walking in patients with knee osteoarthritis: protocol for a cross-sectional study.Frontiers in aging neuroscience · 2025Article
- Bridging the gap: Exploring the intercurrent relationship between knee osteoarthritis and cerebral small vessel disease.Caspian journal of internal medicine · 2025Review
- Altered activation patterns of the sensory-motor cortex in patients with knee osteoarthritis during knee isokinetic movement at different speeds.Frontiers in bioengineering and biotechnology · 2024Article
- Structural and functional brain changes in people with knee osteoarthritis: a scoping review.PeerJ · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Functional and structural alterations in the gray matter have been observed in patients with knee osteoarthritis (KOA). However, little is known about white matter changes in KOA. Here, we evaluated fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) to investigate potential alterations in the white matter of patients with KOA. Methods: A total of 166 patients with KOA, along with 88 age- and sex-matched healthy controls were recruited and underwent brain magnetic resonance imaging (MRI). Diffusion tensor imaging (DTI) data were collected and analyzed using tract-based spatial statistics (TBSS). Statistical significances were determined at Results: FA values for the body of corpus callosum, splenium of corpus callosum, bilateral superior longitudinal fasciculus, cingulum, bilateral superior corona radiata, and right posterior corona radiata were significantly higher in patients with KOA than in healthy controls ( Conclusion: Patients with KOA exhibited extensive white matter alterations in sensorimotor and pain-related regions. Longitudinal observation studies on the causation between abnormalities in the white matter tracts and KOA is needed in the future.
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