ArticleFrontiers in psychiatry2022
Neurodevelopmental Trajectories in Children With Internalizing, Externalizing and Emotion Dysregulation Symptoms.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Maternal Childhood Maltreatment, Development of Amygdala Volume, and Anxiety Symptoms in Offspring.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Understanding the developmental trajectory of behavioral problems and subcortical structure morphometry in healthy children at 6 years old and long-term impact of early nutrition: the COGNIS study.Child and adolescent psychiatry and mental health · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- A two-year longitudinal investigation of insula subregional cortical thickness and surface area in early psychosis.Schizophrenia research · 2025Article
- Contrastive functional connectivity defines neurophysiology-informed symptom dimensions in major depression.Cell reports. Medicine · 2025Article
- A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations.Nature. Mental health · 2024Article
- Preadolescent externalizing and internalizing symptoms are differentially related to drift-diffusion model parameters and neural activation during a go/no-go task.Journal of psychiatric research · 2024Article
- Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.Neuroimage. Reports · 2024Article
- Stage 2 Registered Report: The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm.medRxiv : the preprint server for health sciences · 2023Article
- Brain Structure Relations With Psychopathology Trajectories in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Deviations from normative brain white and gray matter structure are associated with psychopathology in youth.Developmental cognitive neuroscience · 2022Article
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5 authors.
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Abstract
Introduction: Childhood and adolescence are crucial periods for brain and behavioral development. However, it is not yet clear how and when deviations from typical brain development are related to broad domains of psychopathology. Methods: Using three waves of neuroimaging data within the population-based Generation R Study sample, spanning a total age range of 6-16 years, we applied normative modeling to establish typical development curves for (sub-)cortical volume in 37 brain regions, and cortical thickness in 32 brain regions. Z-scores representing deviations from typical development were extracted and related to internalizing, externalizing and dysregulation profile (DP) symptoms. Results: Normative modeling showed regional differences in developmental trajectories. Psychopathology symptoms were related to negative deviations from typical development for cortical volume in widespread regions of the cortex and subcortex, and to positive deviations from typical development for cortical thickness in the orbitofrontal, frontal pole, pericalcarine and posterior cingulate regions of the cortex. Discussion: Taken together, this study charts developmental curves across the cerebrum for (sub-)cortical volume and cortical thickness. Our findings show that psychopathology symptoms, are associated with widespread differences in brain development, in which those with DP symptoms are most heavily affected.
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