Evidence map›Paper›PMID 35370800›Full record

ReviewFrontiers in physiology2022

Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique.

Balázs Horváth, Norbert Szentandrássy, Csaba Dienes, Zsigmond M Kovács, Péter P Nánási, Ye Chen-Izu, Leighton T Izu, Tamas Banyasz

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Balázs HorváthDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Norbert SzentandrássyDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Csaba DienesDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Zsigmond M KovácsDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Péter P NánásiDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Ye Chen-IzuDepartment of Pharmacology, University of California, Davis, Davis, CA, United States.
Leighton T IzuDepartment of Pharmacology, University of California, Davis, Davis, CA, United States.
Tamas BanyaszDepartment of Physiology, University of Debrecen, Debrecen, Hungary.

Funding

Mechanical Load Effects on Cardiac Function and Heart DiseasesR35HL166575 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ye Chen-Izu · 2023 to 2026
$4.4M
The Functional Connectome of the Mechanically Loaded CardiomyocyteR01HL149431 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE, IZU, LEIGHTON T. · 2020 to 2023
$2.7M
MECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLINGR01HL141460 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2019 to 2022
$2.6M
Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8M
Decipher Mechano-Chemo-Transduction Pathway and Function in CardiomyocytesR01HL159993 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2021 to 2022
$1.5M
NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL141460NHLBI NIH HHS R01 HL149431NHLBI NIH HHS R01 HL159993NHLBI NIH HHS R35 HL166575
6 · The paper itself

Abstract

The patch clamp technique underwent continual advancement and developed numerous variants in cardiac electrophysiology since its introduction in the late 1970s. In the beginning, the capability of the technique was limited to recording one single current from one cell stimulated with a rectangular command pulse. Since that time, the technique has been extended to record multiple currents under various command pulses including action potential. The current review summarizes the development of the patch clamp technique in cardiac electrophysiology with special focus on the potential applications in integrative physiology.

Indexed as

action potential voltage clampcardiac electrophysiologyion currentpharmacologyvoltage clamp

Identifiers

PMID35370800
PMCPMC8966222

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.