Evidence map›Paper›PMID 35370577›Full record

ArticleFrontiers in human neuroscience2022

Spatial and Temporal Distribution of Information Processing in the Human Dorsal Anterior Cingulate Cortex.

Conor Keogh, Alceste Deli, Amir Puyan Divanbeighi Zand, Mark Jernej Zorman, Sandra G Boccard-Binet, Matthew Parrott, Charalampos Sigalas, Alexander R Weiss, John Frederick Stein, James J FitzGerald and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Conor KeoghNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Alceste DeliNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Amir Puyan Divanbeighi ZandNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Mark Jernej ZormanNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Sandra G Boccard-BinetNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Matthew ParrottSt Hilda's College, University of Oxford, Oxford, United Kingdom.
Charalampos SigalasDepartment of Pharmacology, University of Oxford, Oxford, United Kingdom.
Alexander R WeissDepartment of Neurology, Johns Hopkins University, Baltimore, MD, United States.
John Frederick SteinDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
James J FitzGeraldNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Tipu Z AzizNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Alexander L GreenNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Martin John GilliesNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBJohns Hopkins University · US

Funding

British Heart Foundation PG/19/67/34607
6 · The paper itself

Abstract

The dorsal anterior cingulate cortex (dACC) is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, the dynamics of information flow in this complex region and how it responds to inputs remain unclear and are difficult to study using non-invasive electrophysiology. The area is targeted by neurosurgery to treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from this region in humans during a decision-making task requiring motor output. We investigated the spatial and temporal distribution of information flow within the dACC. We demonstrate the existence of a distributed network within the anterior cingulate cortex where discrete nodes demonstrate directed communication following inputs. We show that this network anticipates and responds to the valence of feedback to actions. We further show that these network dynamics adapt following learning. Our results provide evidence for the integration of learning and the response to feedback in a key cognitive region.

Indexed as

decision makingelectrophysiologyerrorhuman cortexinformation theory

Identifiers

PMID35370577
PMCPMC8973009
OpenAlexW4220996113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.