Evidence map›Paper›PMID 35370235›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma.

Hirofumi Makino, Masakazu Notsu, Itsuko Asayama, Hazuki Otani, Miwa Morita, Masahiro Yamamoto, Mika Yamauchi, Mika Nakao, Hitomi Miyake, Asuka Araki and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hirofumi MakinoInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Masakazu NotsuInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Itsuko AsayamaInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Hazuki OtaniInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Miwa MoritaInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Masahiro YamamotoInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Mika YamauchiInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Mika NakaoCancer Genome Medical Center, Shimane University Faculty of Medicine, Japan.
Hitomi MiyakeDepartment of Internal Medicine, Unnan City Hospital, Japan.
Asuka ArakiOrgan Pathology Unit, Department of Pathology, Shimane University Faculty of Medicine, Japan.
Shinya UchinoNoguchi Thyroid Clinic and Hospital Foundation, Japan.
Keizo KanasakiInternal Medicine 1, Shimane University Faculty of Medicine, Japan.
Shimane University · JPNoguchi Thyroid Clinic and Hospital Foundation · JPOno Pharmaceutical (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parathyroid carcinoma (PC) is a rare type of endocrine cancer. Recurrence and metastasis are common after surgery, and refractory hypercalcemia often leads to a poor prognosis. However, there are currently no specific strategies for PC recurrence. We herein report a 61-year-old Japanese man with metastatic PC who was treated with sorafenib, a multikinase inhibitor. In this case, the serum calcium level was under control for 10 months after the initiation of sorafenib. This case suggests that combination therapy with sorafenib, evocalcet, and denosumab may be an alternative, stronger management option for refractory hypercalcemia in recurrent PC.

Indexed as

HypercalcemiaParathyroid NeoplasmsDenosumabHumansMaleMiddle AgedNaphthalenesNeoplasm Recurrence, LocalParathyroid HormonePyrrolidinesSorafenibDenosumabevocalcetNaphthalenesParathyroid HormonePyrrolidinesSorafenibCDC73hypercalcemiaparathyroid carcinomaprimary hyperparathyroidismsorafenib

Identifiers

PMID35370235
PMCPMC9751735
OpenAlexW4226014559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.