Evidence map›Paper›PMID 35370020›Full record

ArticleVaccine2022

Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccination.

Hideaki Kato, Kei Miyakawa, Norihisa Ohtake, Yutaro Yamaoka, Satoshi Yajima, Etsuko Yamazaki, Tomoko Shimada, Atsushi Goto, Hideaki Nakajima, Akihide Ryo

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hideaki KatoInfection Prevention and Control Department, Yokohama City University Hospital, Yokohama, Japan; Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan.
Kei MiyakawaDepartment of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.
Norihisa OhtakeBioscience Division, Research and Development Department, Tosoh Corporation, Tokyo Research Center, Kanagawa, Japan; Advanced Medical Research Center, Yokohama City University, Yokohama, Japan.
Yutaro YamaokaDepartment of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan; Life Science Laboratory, Technology and Development Division, Kanto Chemical Co, Inc., Isehara, Japan.
Satoshi YajimaClinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan.
Etsuko YamazakiClinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan.
Tomoko ShimadaNursing Department, Yokohama City University Hospital, Yokohama, Japan.
Atsushi GotoDepartment of Health Data Science, Yokohama City University Graduate School of Data Science, Yokohama, Japan.
Hideaki NakajimaDepartment of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan.
Akihide RyoDepartment of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan. Electronic address: aryo@yokohama-cu.ac.jp.
Yokohama City University · JPYokohama City University Hospital · JPKanto Chemical (Japan) · JPTosoh (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate vaccine-induced humoral and cell-mediated immunity at 6 months after completion of two doses of BNT162b2 vaccination, immunoglobulin G against SARS-CoV-2 spike protein (SP IgG), 50% neutralizing antibody (NT

Indexed as

COVID-19SARS-CoV-2AdultAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineHumansImmunity, CellularImmunity, HumoralImmunoglobulin GSpike Glycoprotein, CoronavirusVaccinationAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-250% neutralization titerCell-mediated immunityCoronavirus disease-2019Interferon-γ releasing ELISpot assayVaccinationVariant of concern

Identifiers

PMID35370020
PMCPMC8960126
OpenAlexW4220983234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.