ArticleLipids in health and disease2022
Eradication of Helicobacter pylori alleviates lipid metabolism deterioration: a large-cohort propensity score-matched analysis.
Article in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Outcomes ofGastroenterology and hepatology from bed to bench · 2026Review
- Helicobacter pylori infection increases the risk of dyslipidemia in Chinese non-obese and non-diabetic population from the perspective of age category: a retrospective cross-sectional study.BMC infectious diseases · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and Helicobacter pylori infection.Scientific reports · 2025Article
- Article
- Article
- Retrospective cohort study ofFrontiers in public health · 2025Article
- Metabolic reprogramming inFrontiers in cellular and infection microbiology · 2025Review
- Association of lifestyle change after H. pylori eradication with cardiovascular disease: a nationwide Korean NHIS cohort study.BMJ public health · 2025Article
- Article
- The Interplay betweenInternational journal of molecular sciences · 2023Review
- The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study.Thrombosis journal · 2023Article
- Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions.Microbiology spectrum · 2023Article
- Infection withFrontiers in pharmacology · 2023Review
- Effect of Helicobacter pylori eradication on metabolic profile: an international, multicenter, case-control study.BMC gastroenterology · 2022Article
- Spice Intake Among Chronic Gastritis Patients and Its Relationship With Blood Lipid Levels in South India.Cureus · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
backgroundThe impact of Helicobacter pylori (H. pylori) eradication on metabolism of lipid and the potential predictor of such changes remain unclear.
methodsThis study retrospectively included subjects who underwent at least two
resultsAfter propensity score matching, 3412 matched cases were analyzed. Within-group comparisons showed significantly decreased HDL (P < 0.001) and increased LDL (P < 0.001) at the second examination in both the HPE and HPP groups. Between-group comparisons showed that the HDL decrease of the HPE group was significantly larger and smaller when compared with the HPN (P = 0.001) and HPP (P = 0.004) group, respectively. Uni- and multivariate analyses showed that low diastolic blood pressure (DBP) (P = 0.002) and high mean platelet volume (MPV) (P = 0.001) before eradication were associated with increased HDL after eradication. Low total protein (TP) (P < 0.001) was associated with decreased LDL after eradication.
conclusionsCompared with sustained H. pylori infectious states, H. pylori eradication alleviated the lipid metabolism deterioration but did not restore it to the uninfected level within 1.5 years after eradication. Patients with low DBP, high MPV, and low TP may reap a greater lipid-metabolism benefit from H. pylori eradication.
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