Evidence map›Paper›PMID 35369761›Full record

ReviewPharmaceutical patent analyst2022

Small-molecule inhibitors of Slack potassium channels as potential therapeutics for childhood epilepsies.

Alshaima'a M Qunies, Kyle A Emmitte

Open access · greenAbstract readReview
In one paragraph

Review in Pharmaceutical patent analyst, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Journal of medicinal chemistry · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alshaima'a M QuniesDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0003-4922-8682
Kyle A EmmitteDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-6643-3947
University of North Texas · US

Funding

Slack Potassium Channel Inhibitors for the Treatment of Childhood EpilepsiesR33NS109521 · NINDS · VANDERBILT UNIVERSITY · PI EMMITTE, KYLE A, WEAVER, C DAVID · 2020 to 2021
$787k
Discovery of small molecule activators of the Slack potassium channel for use as cell-based probes for the study of fragile X syndromeR21MH125257 · NIMH · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI EMMITTE, KYLE A, WEAVER, C DAVID · 2021 to 2022
$428k
NIMH NIH HHS R21 MH125257NINDS NIH HHS R33 NS109521NINDS NIH HHS R33NS109521
6 · The paper itself

Abstract

Slack channels are sodium-activated potassium channels that are encoded by the

Indexed as

EpilepsyNerve Tissue ProteinsPotassium Channel BlockersPotassium Channels, Sodium-ActivatedChildHumansMutationQuinidineSeizuresKCNT1 protein, humanNerve Tissue ProteinsPotassium Channel BlockersPotassium Channels, Sodium-ActivatedQuinidine1,2,4-oxadiazole5-chlorindanylEIMFSKCNT1KNa1.1MMPSISlackSlo2.2

Identifiers

PMID35369761
PMCPMC9260495
OpenAlexW4226056305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.