Evidence map›Paper›PMID 35369719›Full record

ArticleJournal of neurotrauma2022

Plasma Neurofilament Light and Glial Fibrillary Acidic Protein Levels over Thirty Days in a Porcine Model of Traumatic Brain Injury.

Samuel S Shin, Marco M Hefti, Vanessa M Mazandi, David A Issadore, David F Meaney, Andrea L C Schneider, Ramon Diaz-Arrastia, Todd J Kilbaugh

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Samuel S ShinDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Marco M HeftiDepartment of Pathology, University of Iowa, Iowa City, Iowa, USA.
Vanessa M MazandiDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David A IssadoreDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David F MeaneyDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrea L C SchneiderDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ramon Diaz-ArrastiaCenter for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Todd J KilbaughDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USUniversity of Iowa · US

Funding

Novel tau-based diagnostics for neonatal hypoxic-ischemic injuryK23NS109284 · NINDS · UNIVERSITY OF IOWA · PI HEFTI, MARCO MATTHIAS · 2019 to 2023
$950k
NINDS NIH HHS K23 NS109284
6 · The paper itself

Abstract

To establish the clinical relevance of porcine model of traumatic brain injury (TBI) using the plasma biomarkers of injury with diffusion tensor imaging (DTI) over 30 days, we performed a randomized, blinded, pre-clinical trial using Yorkshire pigs weighing 7-10 kg. Twelve pigs were subjected to Sham injury (

Indexed as

Brain Injuries, TraumaticDiffusion Tensor ImagingAnimalsBiomarkersGlial Fibrillary Acidic ProteinIntermediate FilamentsSwineBiomarkersGlial Fibrillary Acidic Proteindiffusion tensor imagingglial fibrillary acidic proteinneurofilament lightpigporcinetraumatic brain injury

Identifiers

PMID35369719
PMCPMC9836679
OpenAlexW4226337130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.