Evidence map›Paper›PMID 35369443›Full record

ArticleFrontiers in microbiology2022

A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With

Chih-Yuan Chiang, Douglas J Lane, Yefen Zou, Tim Hoffman, Jianfeng Pan, Janice Hampton, Jillian Maginnis, Bishnu P Nayak, Ugo D'Oro, Nicholas Valiante and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Human anthrax vaccines: Current status and future prospects.Human vaccines & immunotherapeutics · 2025
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Chih-Yuan ChiangDivision of Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Douglas J LaneDivision of Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Yefen ZouGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Tim HoffmanGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Jianfeng PanGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Janice HamptonGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Jillian MaginnisGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Bishnu P NayakGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Ugo D'OroNovartis Vaccines and Diagnostics, Siena, Italy.
Nicholas ValianteNovartis Vaccines and Diagnostics, Cambridge, MA, United States.
Andrew T MillerGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Michael CookeGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Tom WuGenomics Institute of the Novartis Research Foundation, San Diego, CA, United States.
Sina BavariDivision of Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Rekha G PanchalDivision of Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Genomics Institute of the Novartis Research Foundation · USUnited States Army Medical Research Institute of Infectious Diseases · USNewron Pharmaceuticals (Italy) · ITNovartis (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current therapies for anthrax include the use of antibiotics (i.e., doxycycline, and ciprofloxacin), an anthrax vaccine (BioThrax) and

Indexed as

agonistBacillus anthracisin vivoprophylacticTLR2

Identifiers

PMID35369443
PMCPMC8965344
OpenAlexW4220847234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.