Evidence map›Paper›PMID 35369301›Full record

ArticleFrontiers in cardiovascular medicine2022

Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network.

Kyung In Baek, Shyr-Shea Chang, Chih-Chiang Chang, Mehrdad Roustaei, Yichen Ding, Yixuan Wang, Justin Chen, Ryan O'Donnell, Hong Chen, Julianne W Ashby and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Microfluidic Device Type Improves Heart mRNA DeliveryLangmuir : the ACS journal of surfaces and colloids · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Hemodynamic regulation allows stable growth of microvascular networks.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Kyung In BaekDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Shyr-Shea ChangDepartment of Mathematics, University of California, Los Angeles, Los Angeles, CA, United States.
Chih-Chiang ChangDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Mehrdad RoustaeiDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Yichen DingDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Yixuan WangDepartment of Mathematics, University of California, Los Angeles, Los Angeles, CA, United States.
Justin ChenDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Ryan O'DonnellDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
Hong ChenVascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Julianne W AshbyDivision of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Xiaolei XuZebrafish Genetics, Mayo Clinic, Rochester, MN, United States.
Julia J MackDivision of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Susana CavalleroDivision of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Marcus RoperDepartment of Mathematics, University of California, Los Angeles, Los Angeles, CA, United States.
Tzung K HsiaiDepartment of Medicine and Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USBoston Children's Hospital · USMayo Clinic in Florida · USVA Greater Los Angeles Healthcare System · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Epsin in Angiogenesis and Vascular RemodelingR01HL093242 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CHEN, HONG, WANG, DA-ZHI · 2009 to 2021
$7.3M
Mechanisms regulating VEGF receptors in diabetic angiogenesisR01HL130845 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, XU, JIAN · 2016 to 2023
$4.9M
The role of signaling adaptor protein epsin in atherosclerosisR01HL156362 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2021 to 2024
$3.1M
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in AtherosclerosisR01HL162367 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2022 to 2025
$3.0M
Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Molecular Mechanisms Regulating Endothelial DysfunctionR01HL137229 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2017 to 2020
$2.7M
Integrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and FunctionR01HL159970 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2021 to 2024
$2.0M
Integrating imaging and computation to characterize neural crest cells in the myocardial development and regenerationR00HL148493 · NHLBI · UNIVERSITY OF TEXAS DALLAS · PI DING, YICHEN · 2020 to 2022
$730k
Optimality in the zebrafish microvasculatureR01GM126556 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROPER, MARCUS · 2017 to 2020
$606k
NCI NIH HHS P30 CA008748NHLBI NIH HHS R00 HL148493NHLBI NIH HHS R01 HL093242NHLBI NIH HHS R01 HL130845NHLBI NIH HHS R01 HL137229NHLBI NIH HHS R01 HL149808NHLBI NIH HHS R01 HL156362NHLBI NIH HHS R01 HL159970NHLBI NIH HHS R01 HL162367NIGMS NIH HHS R01 GM126556
6 · The paper itself

Abstract

Mechano-responsive signaling pathways enable blood vessels within a connected network to structurally adapt to partition of blood flow between organ systems. Wall shear stress (WSS) modulates endothelial cell proliferation and arteriovenous specification. Here, we study vascular regeneration in a zebrafish model by using tail amputation to disrupt the embryonic circulatory loop (ECL) at 3 days post fertilization (dpf). We observed a local increase in blood flow and peak WSS in the Segmental Artery (SeA) immediately adjacent to the amputation site. By manipulating blood flow and WSS via changes in blood viscosity and myocardial contractility, we show that the angiogenic Notch-ephrinb2 cascade is hemodynamically activated in the SeA to guide arteriogenesis and network reconnection. Taken together, ECL amputation induces changes in microvascular topology to partition blood flow and increase WSS-mediated Notch-ephrinb2 pathway, promoting new vascular arterial loop formation and restoring microcirculation.

Indexed as

biophysicsNotch-ephrinb2 signalingpeak wall shear stressvascular injury and repairvascular loop formation

Identifiers

PMID35369301
PMCPMC8971683
OpenAlexW4225966425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.