Evidence map›Paper›PMID 35368872›Full record

ArticleOxidative medicine and cellular longevity2022

Circadian Rhythm Modulates the Therapeutic Activity of Pulsed Electromagnetic Fields on Intervertebral Disc Degeneration in Rats.

Yi Zheng, Yiming Hao, Bing Xia, Liangwei Mei, Shengyou Li, Xue Gao, Teng Ma, Bin Wei, Zhifen Tan, Pingheng Lan and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Yi ZhengDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Yiming HaoDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Bing XiaDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Liangwei MeiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Shengyou LiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Xue GaoFaculty of Life Sciences, Northwest University, Xi'an, China 710069.
Teng MaDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Bin WeiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.
Zhifen TanCollege of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang, China 712046.
Pingheng LanDepartment of Orthopedics, The First Affiliated Hospital of Xiamen University, Xiamen University, Fujian, China 361102.
Zhuojing LuoDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.ORCID https://orcid.org/0000-0002-0671-8553
Da JingDepartment of Biomedical Engineering, Fourth Military Medical University, Xi'an, China 710032.ORCID https://orcid.org/0000-0001-8823-4124
Jinghui HuangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, China 710032.ORCID https://orcid.org/0000-0002-0991-0591
Xijing Hospital · CNAir Force Medical University · CNFirst Affiliated Hospital of Xiamen University · CNNorthwest University · CNShaanxi University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythm (CR) imparts significant benefits in treating multiple diseases, such as heart diseases and arthritis. But the CR effect on intervertebral disc degeneration (IVDD) therapy remains unclear. Recent studies revealed that pulsed electromagnetic fields (PEMF) are capable of alleviating IVDD. In this study, we evaluated the CR-mediated regulation of PEMF therapeutic effect on IVDD induced by rat tail disc needle puncture. Our results demonstrated that the daytime PEMF stimulation (DPEMF) is more effective than the nighttime PEMF (NPEMF) in delaying IVDD. Moreover, the rats treated with DPEMF maintained better disc stability and histology after 8 weeks, relative to NPEMF. CR and PEMF cotherapies were also examined in cellular models, whereby serum shock was used to induce different levels of clock gene expression in the nucleus pulposus (NP), thus imitating CR

Indexed as

Intervertebral Disc DegenerationNucleus PulposusAnimalsCircadian RhythmElectromagnetic FieldsRats

Identifiers

PMID35368872
PMCPMC8975688
OpenAlexW4220928227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.